Table 2 Description of 18 pathways in InnateDB that were significantly ( P  < 0.05) up-regulated and 3 pathways significantly downregulated in peritoneal exudate cells from cats with FIP compared to peritoneal cells from healthy cats
Pathway name | Genes in InnateDB | Dysregulated gene count | P adjusted |
|---|---|---|---|
InnateDB pathways that were significantly upregulated | |||
 Toll-like receptor signaling pathway | 67 | 28 | 1.47E−06 |
 RIG-I-like receptor signaling pathway | 42 | 21 | 2.23E−06 |
 Cytokine–cytokine receptor interaction | 148 | 45 | 5.97E−06 |
 Apoptosis | 60 | 24 | 3.26E−05 |
 Cytosolic DNA-sensing pathway | 34 | 17 | 3.97E−05 |
 Graft-versus-host disease | 13 | 10 | 4.33E−05 |
 Hepatitis C | 80 | 27 | 2.48E−04 |
 Leishmaniasis | 41 | 17 | 6.61E−04 |
 Allograft rejection | 14 | 9 | 9.82E−04 |
 Type I diabetes mellitus | 18 | 10 | 0.00170 |
 Jak-STAT signaling pathway | 90 | 26 | 0.00404 |
 Chagas disease (American trypanosomiasis) | 72 | 22 | 0.00539 |
 African trypanosomiasis | 25 | 11 | 0.00712 |
 Osteoclast differentiation | 80 | 23 | 0.00838 |
 Natural killer cell mediated cytotoxicity | 66 | 20 | 0.00867 |
 Autoimmune thyroid disease | 15 | 8 | 0.00896 |
 Toxoplasmosis | 78 | 21 | 0.02566 |
 NOD-like receptor signaling pathway | 36 | 12 | 0.03707 |
InnateDB pathways that were significantly downregulated | |||
 DNA replication | 29 | 18 | 5.21E−04 |
 Cell cycle | 82 | 34 | 0.00446 |
 Basal cell carcinoma | 32 | 17 | 0.00808 |