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Table 2 Description of 18 pathways in InnateDB that were significantly ( P  < 0.05) up-regulated and 3 pathways significantly downregulated in peritoneal exudate cells from cats with FIP compared to peritoneal cells from healthy cats

From: Characterization of peritoneal cells from cats with experimentally-induced feline infectious peritonitis (FIP) using RNA-seq

Pathway name Genes in InnateDB Dysregulated gene count P adjusted
InnateDB pathways that were significantly upregulated
 Toll-like receptor signaling pathway 67 28 1.47E−06
 RIG-I-like receptor signaling pathway 42 21 2.23E−06
 Cytokine–cytokine receptor interaction 148 45 5.97E−06
 Apoptosis 60 24 3.26E−05
 Cytosolic DNA-sensing pathway 34 17 3.97E−05
 Graft-versus-host disease 13 10 4.33E−05
 Hepatitis C 80 27 2.48E−04
 Leishmaniasis 41 17 6.61E−04
 Allograft rejection 14 9 9.82E−04
 Type I diabetes mellitus 18 10 0.00170
 Jak-STAT signaling pathway 90 26 0.00404
 Chagas disease (American trypanosomiasis) 72 22 0.00539
 African trypanosomiasis 25 11 0.00712
 Osteoclast differentiation 80 23 0.00838
 Natural killer cell mediated cytotoxicity 66 20 0.00867
 Autoimmune thyroid disease 15 8 0.00896
 Toxoplasmosis 78 21 0.02566
 NOD-like receptor signaling pathway 36 12 0.03707
InnateDB pathways that were significantly downregulated
 DNA replication 29 18 5.21E−04
 Cell cycle 82 34 0.00446
 Basal cell carcinoma 32 17 0.00808