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Table 1 Safety

From: Oral vaccination of dogs: a well-studied and undervalued tool for achieving human and dog rabies elimination

Vaccine Nb dogs Age Dog characteristics Country Administration Dose per animal Observation period (days) Rabies virus positive at the end of the trial Source
Brains Salivary glands Salivary swabs
SAG2 6   Laboratory dogs   Oral instillation 108.5 TCID50 3–35 0   0 [13]
  6   Laboratory dogs   Brachial nerve plexus 108.5 TCID50 3–35 0   0  
SAG2 21 < 3 months (N = 10
3–12 months (N = 3)
> 1 year (N = 8)
Indigenous dogs Tunisia Oral instillation 109.5 TCID50 90 or 180 0 0   [34]
SAG2 4 6–12 months Laboratory dogs India DBL2 bait 108.5 TCID50 219 0 0   [24]
  5 (immuno depressed) 6–12 months Laboratory dogs   DBL2 bait 108.5 TCID50 219 0 0   
  3 6–12 months Laboratory dogs   Control 219 0 0   
SAG2 5 Adult Laboratory beagles CDC, US Rabigen Oral 108.2 TCID50 42–49 0    [23]
  3 Adult Laboratory beagles   Rabigen Oral 107.5 TCID50 42–49 0    
  5 Adult Laboratory beagles   Rabigen Oral 107.4 TCID50 42–49 0    
  5 Adult Laboratory beagles   DBL2 bait 108.3 TCID50 42–49 0    
  4 Adult Laboratory beagles   DBL2 bait 107.2 TCID50 42–49 0    
  4 Adult Laboratory beagles   DBL2 bait 106.9 TCID50 42–49 0    
SAG2 10 7–10 weeks Indigenous dogs South Africa IM 109.0 TCID50 120 0 0 8/10: positive 1 h post-admin, but not later [36]
  10 7–10 weeks Indigenous dogs South Africa Oral instillation 109.0 TCID50 120 0 0 7/10:positive 1 h post-admin, but not later  
  1 7–10 weeks Indigenous dogs South Africa Contact control 120 0 0   
SAD B19 8 < 10 weeks Free-roaming indigenous dogs Turkey Oral instillation 2.4 × 107 PFU 40–81 0    [35]
  2 < 10 weeks    Parenteral 2.4 × 107 PFU 27–28 0    
  12 < 10 weeks    Oral instillation 4.2 × 108 PFU 24–97 0    
  6 < 10 weeks    Parenteral 108 PFU 30–69 0    
SAD B19 4 6 months Free-roaming indigenous dogs Turkey IC 2.5 × 107 PFU (4th passage IC in foxes) 40     [35]
V-RG 6   Indigenous dogs Tunisia Oral instillation 108.5 TCID50 123     [78]
  6     Oral instillation 109.5 TCID50 123     
VRC-RZ2 6 3–12 months Indigenous dogs Kazakhstan Bait 107.7 TCID50 20    0/6 tested 5 and 10 days post-adm [33]
  1. DBL2: dog bait lyophilized (freeze-dried SAG2 bait), IC: intracerebrally, IM: intramuscularly, PFU: plaque forming units, TCID50: median tissue culture infectious doses.