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Figure 3 | Veterinary Research

Figure 3

From: Cooperation of PD-1 and LAG-3 in the exhaustion of CD4+ and CD8+ T cells during bovine leukemia virus infection

Figure 3

Expression of PD-1 and LAG-3 on γδ T cells in BLV-infected cattle. A Gating strategy and representative dot plots for expression analyses of PD-1 and LAG-3 on IgMCD3+CD8γδTCR+ T cells from peripheral blood of BLV-infected cattle (AL and EBL). Values in the quadrants indicate percentages of cells. Percentages of PD-1+LAG-3+CD8 γδ T cells (B), PD-1+LAG-3CD8 γδ T cells (C), and PD-1LAG-3+CD8 γδ T cells (D) in CD3+CD8 γδ T-cell population in peripheral blood from BLV − (n = 6), AL (n = 13), PL (n = 5), and EBL cattle (n = 6). Bars indicate group median percentage. Significant differences between each group were determined using a Kruskal–Wallis test.

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