Figure 3
Microscopic lesions and viral antigen localization in the bone marrow of adult rabbits (Oryctolagus cuniculus) inoculated with Lagovirus europaeus G1.2 (BlMt-1). Arrows denote myeloid cells and arrowheads denote erythroid cells. A Uninfected control (rabbit 130). 600× magnification. B Bone marrow in an earlier stage of acute infection (rabbit 283). Note the decreasing proportion of myeloid to erythroid cells. 600× magnification. C Bone marrow at the terminal stage of acute infection (rabbit 282). Myeloid cells are scarce and erythroid cells at arrowheads are binucleated. 600× magnification. D Immunohistochemical visualization of viral capsid antigen (brown staining) in the cytoplasm of viable macrophages (arrows) in the terminal stage of acute infection (rabbit 282). 400× magnification.