Microscopic lesions in the liver of rabbits (Oryctolagus cuniculus) inoculated with Lagovirus europaeus G1.2 (BlMt-1). Asterisks denote portal areas. Haematoxylin and eosin stain. A Uninfected control rabbit (rabbit 130). 200× magnification. B Earlier stage of acute infection in an adult rabbit (rabbit 283). There is degeneration and death of hepatocytes at the limiting plate and periportally surrounded by intensive heterophilic inflammation. Arrows denote apoptotic cells. 200× magnification. Insert: high magnification of dead hepatocytes surrounded by heterophils. C Terminal stage of acute infection in a 5 week old rabbit (rabbit 303). There is massive hepatocellular degeneration and death. 200× magnification. D Terminal stage of acute infection in a 5 week old rabbit (rabbit 306). Arrowheads denote clusters of heterophils that are seen throughout the lobule and the arrow indicates an area of lytic necrosis. 400× magnification. Insert: high magnification of heterophils surrounding dead hepatocytes.