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Table 2 Gastro-intestinal nematode infection studies that have overlapping genes with our study

From: Exploring the mechanisms of resistance to Teladorsagia circumcincta infection in sheep through transcriptome analysis of abomasal mucosa and abomasal lymph nodes

Animal age/breed

Infection status

Tissue used for study

Nematode species

Genes a

Technique

Study

Yearling Scottish Blackface sheep

Challenged naive sheep

Abomasal mucosa

T. circumcincta

ITLN2, IL4, galectin 14

RT-PCR, Western blot

[9]

Yearling sheep

Immune day 5 vs naïve day 5

Abomasal mucosa

T. circumcincta

CLCA1, PDZK1IP1

cDNA microarray, RT-PCR, QT-PCR

[37]

Yearling sheep

Naive sheep

Abomasal mucosa

T. circumcincta

ITLN2, ITLN1, ITLN3 galectin 4, galectin 1

cDNA microarray, RT-PCR, QT-PCR

[37]

Yearling sheep

Naive day 5 vs naive day 0

Abomasal mucosa

T. circumcincta

LYZ, MMP13

cDNA microarray, RT-PCR, QT-PCR

[37]

6 months old Merino-cross wethers

Infected sheep

Abomasal mucosa

H. contortus

ITLN2, CLCA1, interleukins

Sequential microarray (across all arrays)

[12]

6 months old Merino-cross wethers

Infected sheep

Abomasal mucosa

H. contortus

ALPL, PDZK1IP1

Sequential microarray (day 22 vs day 3 biopsies)

[12]

Lambs

Primary challenge vs Tertiary challenge

Lymph node

T. colubriformis

PPARG, KRT5, SLC31A2, KRT18

micro array data, QT PCR

[13]

Lambs

Resistant sheep

Abomasal mucosa

T. colubriformis, H. contortus

DUOX1, IL2RA, IL10

RT-PCR

[11]

Adult sheep

Immune sheep

Abomasal mucosa

T. circumcincta

LYZ, ITLN2, ITLN3, CLCA, KRT10, KRT8, KRT19

SDS-PAGE and Shortgun proteomics

[44]

Lambs Scottish Blackface

Susceptible sheep

Lymph node

T. circumcincta

SLC30A2, galectin 14

RNA-seq

[14]

1 year old canaria hair breed (CHB) and canaria sheep (CS)

Infected CHB

Abomasal mucosa

H. contortus

galectin 15, IL5, ALPL, MMP1, MMP11, MMP14, MMP2

RNA-seq, RT-PCR

[15]

1 year old canaria hair breed (CHB) and canaria sheep (CS)

Infected CHB and CS

Abomasal mucosa

H. contortus

SLC2A3, IL1RL1

RNA-seq, RT-PCR

[15]

Lambs Scottish Blackface

Resistant vs Control

Lymph node

T. circumcincta

IL5RA, IL13, IL13RA2, IL1RL1, IL4, SLC9A4

cDNA microarray, RT-PCR

[20]

Lambs (Scottish Blackface x Leicester)

Infected sheep

Abomasum, lymph node

T. circumcincta

ITLN2, ITLN1, ITLN3

Semi-quantitative RT-PCR

[10]

  1. aList of genes whose expression level is affected by GIN-infection. Those highlighted in bold font were also identified as GIN-activated differentially expressed genes in our study.