Exploring the mechanisms of resistance to Teladorsagia circumcincta infection in sheep through transcriptome analysis of abomasal mucosa and abomasal lymph nodes

Table 1 Results from enrichment analyses performed on the 71 GIN-activated DEGs up-regulated in resistant sheep identified for abomasal lymph node samples

Database	Name	Nb. of genes	ID	Gene symbol	Statistics**
KEGG pathway analysis	Glycine, serine and threonine metabolism	3	260	ALAS2, PSPH, GLYCTK	C = 32; O = 3; E = 0.03; R = 103.67
	Glycine, serine and threonine metabolism	3	260	ALAS2, PSPH, GLYCTK	rawP = 3.33e−06; adjP = 9.99e−06
	PPAR signaling pathway	3	3320	RXRG, PPARG, AQP7	C = 70; O = 3; E = 0.06; R = 47.39;
	PPAR signaling pathway	3	3320	RXRG, PPARG, AQP7	rawP = 3.59e−05; a djP = 5.39e−05
	Metabolic pathways	7	1100	CMBL, ALAS2, CKMT1A, PSPH, GLYCTK,	C = 1130; O = 7; E = 1.02; R = 6.85;
	Metabolic pathways	7	1100	ALPL, TST	rawP = 6.15e−05; adjP = 6.15e−05
Disease association analysis	Gastrointestinal neoplasms	5	DB_ID:PA444257	KRT20, PGC, B4GALNT2, PPARG, LGALS4	C = 354; O = 5; E = 0.32; R = 15.62
	Gastrointestinal neoplasms	5	DB_ID:PA444257		rawP = 1.66e−05; adjP = 0.0002
	Intestinal diseases	5	DB_ID:PA444632	KRT20, PGC, PPARG, SLC22A4, LGALS4	C = 331; O = 5; E = 0.30; R = 16.70
	Intestinal diseases	5	DB_ID:PA444632		rawP = 1.20e−05; adjP = 0.0002
	Inflammation	5	DB_ID:PA444620	SFTPD, PPARG, PF4, CLCA1, IL5RA	C = 435; O = 5; E = 0.39; R = 12.71
	Inflammation	5	DB_ID:PA444620		rawP = 4.43e−05; adjP = 0.0003
	Gastrointestinal diseases	5	DB_ID:PA444256	KRT20, PGC, PPARG, SLC22A4, LGALS4	C = 413; O = 5; E = 0.37; R = 13.39
	Gastrointestinal diseases	5	DB_ID:PA444256		rawP = 3.46e−05; adjP = 0.0003

**C: the number of reference genes in the category, O: the number of genes in the gene set and also in the category, E: the expected number in the category, R: ratio of enrichment, rawP: P value from hypergeometric test, adjP: P value adjusted by the multiple test adjustment.

ISSN: 1297-9716