Figure 5

Leukocyte cytokine production after IV administration of CNV-NT. Mean ± SD of TNF-α, IL-6 and IL-10 production from canine blood after lipopolysaccharide (LPS), lipoteichoic acid (LTA) or phosphate buffered saline (PBS, control) stimulation at time 0 (pretreatment), and then at 7, 14 and 28 days post IV CNV-NT spore administration. There was significantly greater LPS-induced TNF-α production at 28 days (P = 0.002) (a) and LTA-induced IL-10 production at 7 days (P = 0.009) (b) and 28 days (P = 0.041) (c) compared to baseline.