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Table 3 The differential expression genes in the Δ27735 mutant compared to the WT strain

From: The putative amino acid ABC transporter substrate-binding protein AapJ2 is necessary for Brucella virulence at the early stage of infection in a mouse model

Gene locus Gene products Regulation 2−∆∆Ct ± SD
Replication, recombination and repair
 bab_RS18500 Transposase Up 1.13 ± 0.11
 bab_RS20725 Transposase, is4 family Down 0.81 ± 0.05
Amino acid transport and metabolism
 bab_RS30275 Extracellular ligand-binding receptor Up 1.66 ± 0.44*
Energy production and conversion
 bab_RS30280 NADPH quinone oxidoreductase Up 1.77 ± 0.23*
Post-translational modification, protein turnover, and chaperones
 bab_RS26600 Heat shock protein Up 1.22 ± 0.13
Cell motility
 bab_RS26930 Flagellar motor switch protein Up 1.69 ± 0.17*
 bab_RS31530 Flagellar biosynthesis protein Up 1.53 ± 0.25*
 bab_RS27100 Flagellar L-ring protein Down 0.82 ± 0.16
Transcription
 bab_RS31650 AraC family transcriptional regulator Down 0.73 ± 0.12
 bab_RS29200 IclR family transcriptional regulator Down 0.69 ± 0.07
Defense mechanisms
 bab_RS28255 Type I restriction DNA specific modify protein Down 0.73 ± 0.07
Function unknown
 bab_RS18900 Hypothetical protein Up 1.84 ± 0.56*
 bab_RS30140 LmbE family Up 1.71 ± 0.38*
 bab_RS18875 Putative Gene transfer agent Up 1.70 ± 0.36*
 bab_RS27050 Hrp-dependent Type III effector Up 1.26 ± 0.13
 bab_RS23095 Predicted membrane protein (DUF2306) Up 1.23 ± 0.20
 bab_RS31525 Hypothetical protein Up 1.20 ± 0.35
 bab_RS22085 Hypothetical protein Down 0.76 ± 0.23
 bab_RS27055 Hypothetical protein Down 0.76 ± 0.12
  1. Statistical significance was determined using two-tailed Student’s t test.
  2. *p < 0.05.