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Figure 6 | Veterinary Research

Figure 6

From: Atrophy of primary lymphoid organs induced by Marek’s disease virus during early infection is associated with increased apoptosis, inhibition of cell proliferation and a severe B-lymphopenia

Figure 6

MDV infection induces a significant decrease in B-lymphocytes blood count at early time points. EDTA-blood of each chick was stained with anti-CD4-RPE, anti-CD8-FITC, anti-Bu1-PerCP-Cy5.5, anti-K1-RPE, and anti-CD45-APC in a no-lyse no-wash single-step procedure and analyzed by flow cytometry. Absolute number of T-CD4+ (A), T-CD8+ (B) and B lymphocytes (C) per µL of blood is given for most birds at each time point (6, 10 and 14 dpi). A few birds are missing because of partial blood clotting detected by cytometry. The median is represented with a black line. A significant increase was observed for T CD4+ cells at 10 dpi and for T CD8+ cells at all time points with a peak at day 10. Inversely, a significant decrease between 90 and 67% was observed for B-cells at 6, 10 and 14 dpi

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Veterinary Research

ISSN: 1297-9716