Effect | Adjuvant | Site | Time | # Adjuvanta | # Sitea | # Timea | Estimate | Lowerb | Upperb | p value | Sample | Titer |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Adjuvant | Alum–Saponin–Oil | – | – | Alum–Saponin | – | – | +1.6 | +0.7 | +2.5 | 0.0012 | Milk | IgG2 |
Alum–Oil | – | – | +1.5 | +0.9 | +2.1 | < 0.0001 | Serum | IgG2 | ||||
Adjuvant × time | Alum–Saponin–Oil | – | Prime | Alum–Saponin–Oil | – | Boost | −2.3 | −3.1 | −1.5 | < 0.0001 | Milk | IgG1 |
−2.0 | −2.3 | −1.7 | < 0.0001 | Serum | IgA | |||||||
−1.8 | −2.3 | −1.3 | < 0.0001 | Serum | IgG1 | |||||||
– | Boost | Alum–Saponin | – | Boost | +2.6 | +1.9 | +3.4 | < 0.0001 | Serum | IgG1 | ||
+2.5 | +1.4 | +3.5 | <Â 0.0001 | Milk | IgG1 | |||||||
+1.9 | +1.3 | +2.6 | <Â 0.0001 | Serum | IgA | |||||||
+1.6 | +0.7 | +2.5 | 0.0011 | Milk | IgA | |||||||
– | Boost | Alum–Oil | – | Boost | +1.8 | +1.0 | +2.6 | < 0.0001 | Serum | IgG1 | ||
Adjuvant × site | Alum–Saponin–Oil | Udder | – | Alum–Saponin | Udder | – | +2.6 | +1.4 | +3.8 | < 0.0001 | Milk | IgG1 |
Udder | – | Alum–Oil | Udder | – | +1.9 | +0.6 | +3.3 | 0.0069 | Milk | IgG1 | ||
Alum–Oil | Neck | – | Alum–Saponin | Neck | – | +2.1 | +0.9 | +3.2 | 0.0009 | Milk | IgG1 | |
Udder | – | Alum–Oil | Neck | – | −2.1 | −3.4 | −0.9 | 0.0014 | Milk | IgG1 | ||
Site × time | – | Neck | Prime | – | Neck | Boost | −2.0 | −2.4 | −1.6 | < 0.0001 | Milk | IgG2 |
−1.9 | −2.6 | −1.3 | < 0.0001 | Milk | IgG1 | |||||||
−1.8 | −2.2 | −1.4 | < 0.0001 | Milk | NT |