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Figure 3 | Veterinary Research

Figure 3

From: Swinepox virus vector-based vaccines: attenuation and biosafety assessments following subcutaneous prick inoculation

Figure 3

Deletion and wtSPV testing in swine. A Measuring the humoural immune response to the deletion mutants and wtSPV in pigs; B IL-4 and IFN-γ levels post-vaccination. The IL-4 and IFN-γ levels of the deletion mutant and wtSPV group at 30 days post-vaccination. C The deletion mutant and wtSPV groups induce SPV-specific neutralizing antibodies in pigs. The titres of neutralizing antibodies are expressed as the reciprocal of the highest serum dilution, in which no CPE was observed. D Photographic images of SPV deletion mutants and wtSPV at 10 days after inoculation. E Swine weight loss curves at 42 days post-inoculation. The data are shown as the mean ± S.D. Weight loss was analysed by two-way ANOVA (*P < 0.05; ***P < 0.001) for animals. Arrows indicate days on which the deletion mutants and wtSPV demonstrated statistically significant differences from the placebo vaccine.

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