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Table 5 Pathways statistically significantly enriched by PPRV infection in EECs

From: Binding and entry of peste des petits ruminants virus into caprine endometrial epithelial cells profoundly affect early cellular gene expression

Pathway ID Definition Fisher-P value Enrichment_score Genes
Pathway of upregulated genes in PPRV 1 hpi
 chx05140 Leishmaniasis—Capra hircus (goat) 4.22314E−06 5.374365 IL1A//NFKBIA//TGFB3//TNF
 chx04668 TNF signaling pathway—Capra hircus (goat) 1.77336E−05 4.751203 CXCL1//JUNB//NFKBIA//TNF
 chx04380 Osteoclast differentiation—Capra hircus (goat) 3.09217E−05 4.509736 IL1A//JUNB//NFKBIA//TNF
 chx05160 Hepatitis C—Capra hircus (goat) 4.21687E−05 4.37501 CLDN7//IRF1//NFKBIA//TNF
 chx05321 Inflammatory bowel disease (IBD)—Capra hircus (goat) 0.000139054 3.856817 IL1A//TGFB3//TNF
 chx05134 Legionellosis—Capra hircus (goat) 0.000195553 3.708736 CXCL1//NFKBIA//TNF
 chx05133 Pertussis—Capra hircus (goat) 0.000203515 3.691403 IL1A//IRF1//TNF
 chx04210 Apoptosis—Capra hircus (goat) 0.000337929 3.471175 IL1A//NFKBIA//TNF
 chx05323 Rheumatoid arthritis—Capra hircus (goat) 0.000409628 3.387611 IL1A//TGFB3//TNF
 chx05166 HTLV-I infection—Capra hircus (goat) 0.000632975 3.198613 NFKBIA//TGFB3//TNF//ZFP36
Pathway of downregulated genes in PPRV 1 hpi
 There is no enriched pathway    
Pathway of upregulated genes in PPRV 24 hpi
 chx05140 Leishmaniasis—Capra hircus (goat) 0.000419393 3.377379 C3//IL10//NCF1//TLR4
 chx05322 Systemic lupus erythematosus—Capra hircus (goat) 0.002795802 2.553494 C3//CD28//IL10//TROVE2
 chx05205 Proteoglycans in cancer—Capra hircus (goat) 0.002919602 2.534676 ARHGEF1//ESR1//IGF2//MMP2//TLR4
 chx05320 Autoimmune thyroid disease—Capra hircus (goat) 0.002956794 2.529179 CD28//IL10//TSHB
 chx04110 Cell cycle—Capra hircus (goat) 0.003229311 2.49089 BUB1//CCNA2//CCNB1//PCNA
 chx05133 Pertussis—Capra hircus (goat) 0.005551826 2.255564 C3//IL10//TLR4
 chx04914 Progesterone-mediated oocyte maturation—Capra hircus (goat) 0.008113843 2.090773 BUB1//CCNA2//CCNB1
 chx04145 Phagosome—Capra hircus (goat) 0.008982425 2.046606 C3//COLEC12//NCF1//TLR4
 chx05310 Asthma—Capra hircus (goat) 0.009715281 2.012545 IL10//MS4A2
 chx05323 Rheumatoid arthritis—Capra hircus (goat) 0.01065279 1.972537 ANGPT1//CD28//TLR4
Pathway of downregulated genes in PPRV 24 hpi
 chx05205 Proteoglycans in cancer—Capra hircus (goat) 1.05326E−06 5.977465 IQGAP1//MAP2K1//MYC//PLAU//PLAUR//
 chx04380 Osteoclast differentiation—Capra hircus (goat) 3.21792E−06 5.492424 FOS//IL1A//JUNB//MAP2K1//NFKBIA//
 chx04668 TNF signaling pathway—Capra hircus (goat) 1.89215E−05 4.723044 FOS//JUNB//MAP2K1//NFKBIA//SELE//TNF
 chx05020 Prion diseases—Capra hircus (goat) 2.63214E−05 4.57969 EGR1//HSPA5//IL1A//MAP2K1
 chx04662 B cell receptor signaling pathway—Capra hircus (goat) 3.0485E−05 4.515913 FOS//MAP2K1//NFKBIA//NFKBIB//RAC1
 chx05140 Leishmaniasis—Capra hircus (goat) 4.28445E−05 4.368105 FOS//IL1A//NFKBIA//NFKBIB//TNF
 chx05323 Rheumatoid arthritis—Capra hircus (goat) 0.000141883 3.848068 ATP6V1B2//FOS//IL1A//TNF//VEGFA
 chx04621 NOD-like receptor signaling pathway—Capra hircus (goat) 0.000161774 3.791092 HSP90AA1//NFKBIA//NFKBIB//TNF
 chx04660 T cell receptor signaling pathway—Capra hircus (goat) 0.000207727 3.682506 FOS//MAP2K1//NFKBIA//NFKBIB//TNF
 chx04620 Toll-like receptor signaling pathway—Capra hircus (goat) 0.000217362 3.662817 FOS//MAP2K1//NFKBIA//RAC1//TNF