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Table 5 Pathways statistically significantly enriched by PPRV infection in EECs

From: Binding and entry of peste des petits ruminants virus into caprine endometrial epithelial cells profoundly affect early cellular gene expression

Pathway ID

Definition

Fisher-P value

Enrichment_score

Genes

Pathway of upregulated genes in PPRV 1 hpi

 chx05140

Leishmaniasis—Capra hircus (goat)

4.22314E−06

5.374365

IL1A//NFKBIA//TGFB3//TNF

 chx04668

TNF signaling pathway—Capra hircus (goat)

1.77336E−05

4.751203

CXCL1//JUNB//NFKBIA//TNF

 chx04380

Osteoclast differentiation—Capra hircus (goat)

3.09217E−05

4.509736

IL1A//JUNB//NFKBIA//TNF

 chx05160

Hepatitis C—Capra hircus (goat)

4.21687E−05

4.37501

CLDN7//IRF1//NFKBIA//TNF

 chx05321

Inflammatory bowel disease (IBD)—Capra hircus (goat)

0.000139054

3.856817

IL1A//TGFB3//TNF

 chx05134

Legionellosis—Capra hircus (goat)

0.000195553

3.708736

CXCL1//NFKBIA//TNF

 chx05133

Pertussis—Capra hircus (goat)

0.000203515

3.691403

IL1A//IRF1//TNF

 chx04210

Apoptosis—Capra hircus (goat)

0.000337929

3.471175

IL1A//NFKBIA//TNF

 chx05323

Rheumatoid arthritis—Capra hircus (goat)

0.000409628

3.387611

IL1A//TGFB3//TNF

 chx05166

HTLV-I infection—Capra hircus (goat)

0.000632975

3.198613

NFKBIA//TGFB3//TNF//ZFP36

Pathway of downregulated genes in PPRV 1 hpi

 There is no enriched pathway

   

Pathway of upregulated genes in PPRV 24 hpi

 chx05140

Leishmaniasis—Capra hircus (goat)

0.000419393

3.377379

C3//IL10//NCF1//TLR4

 chx05322

Systemic lupus erythematosus—Capra hircus (goat)

0.002795802

2.553494

C3//CD28//IL10//TROVE2

 chx05205

Proteoglycans in cancer—Capra hircus (goat)

0.002919602

2.534676

ARHGEF1//ESR1//IGF2//MMP2//TLR4

 chx05320

Autoimmune thyroid disease—Capra hircus (goat)

0.002956794

2.529179

CD28//IL10//TSHB

 chx04110

Cell cycle—Capra hircus (goat)

0.003229311

2.49089

BUB1//CCNA2//CCNB1//PCNA

 chx05133

Pertussis—Capra hircus (goat)

0.005551826

2.255564

C3//IL10//TLR4

 chx04914

Progesterone-mediated oocyte maturation—Capra hircus (goat)

0.008113843

2.090773

BUB1//CCNA2//CCNB1

 chx04145

Phagosome—Capra hircus (goat)

0.008982425

2.046606

C3//COLEC12//NCF1//TLR4

 chx05310

Asthma—Capra hircus (goat)

0.009715281

2.012545

IL10//MS4A2

 chx05323

Rheumatoid arthritis—Capra hircus (goat)

0.01065279

1.972537

ANGPT1//CD28//TLR4

Pathway of downregulated genes in PPRV 24 hpi

 chx05205

Proteoglycans in cancer—Capra hircus (goat)

1.05326E−06

5.977465

IQGAP1//MAP2K1//MYC//PLAU//PLAUR//

RAC1//SDC4//TNF//VEGFA

 chx04380

Osteoclast differentiation—Capra hircus (goat)

3.21792E−06

5.492424

FOS//IL1A//JUNB//MAP2K1//NFKBIA//

RAC1//TNF

 chx04668

TNF signaling pathway—Capra hircus (goat)

1.89215E−05

4.723044

FOS//JUNB//MAP2K1//NFKBIA//SELE//TNF

 chx05020

Prion diseases—Capra hircus (goat)

2.63214E−05

4.57969

EGR1//HSPA5//IL1A//MAP2K1

 chx04662

B cell receptor signaling pathway—Capra hircus (goat)

3.0485E−05

4.515913

FOS//MAP2K1//NFKBIA//NFKBIB//RAC1

 chx05140

Leishmaniasis—Capra hircus (goat)

4.28445E−05

4.368105

FOS//IL1A//NFKBIA//NFKBIB//TNF

 chx05323

Rheumatoid arthritis—Capra hircus (goat)

0.000141883

3.848068

ATP6V1B2//FOS//IL1A//TNF//VEGFA

 chx04621

NOD-like receptor signaling pathway—Capra hircus (goat)

0.000161774

3.791092

HSP90AA1//NFKBIA//NFKBIB//TNF

 chx04660

T cell receptor signaling pathway—Capra hircus (goat)

0.000207727

3.682506

FOS//MAP2K1//NFKBIA//NFKBIB//TNF

 chx04620

Toll-like receptor signaling pathway—Capra hircus (goat)

0.000217362

3.662817

FOS//MAP2K1//NFKBIA//RAC1//TNF

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