Figure 4
Liver and spleen modifications after the A. marginale challenge. All groups were challenged with 3 × 105 cells/mL A. marginale UFMG2. A The liver histopathology shows hepatocytes binucleation (arrow head) and hydropic degeneration (arrow). B The spleen analysis indicates follicular hyperplasia in the white pulp (asterisk). In contrast, the adjuvant and non-immunized group showed lymphoid follicle atrophies (arrow head). Hematoxylin and eosin staining and scale bar = 100 μm.