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Figure 1 | Veterinary Research

Figure 1

From: In vivo testing of novel vaccine prototypes against Actinobacillus pleuropneumoniae

Figure 1

Immunization and challenge regimen. Immunizations were carried out intra-nasally with a Pasteur pipette and intra-muscularly by injection. Animals were immunized with either a single component or a combination of the following: 30 μg/mL protein (Apfa and/or VacJ), 1.62 × 1010 vesicles/mL OMV. All animals were re-immunized (boosted) 4 weeks after the first immunization. Finally, all pigs were challenged 8 weeks after the first immunization with live A. pleuropneumoniae HK361 via an aerosol chamber. A week after challenge, pigs were euthanized and subjected to necropsy.

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