Table 1 Results of ileal Peyer’s patch samples with reference to BSE status and Obex IHC results
Months pi | Animal ID | Status | Obex (IHC) | Ileal Peyer’s patch | ||
|---|---|---|---|---|---|---|
IHC | PMCA | Tgbov XV mouse bioassay# | ||||
0 (n = 2) (= 1 week pi) | WAIT 17 | Preclinical | neg. | neg. | − | 7/19, 567 ± 43 |
WAIT 18 | Preclinical | neg. | neg. | − | 2/21, 424 ± 76 | |
2 (n = 2) | WAIT 15 | Preclinical | neg. | neg. | + | 12/20, 537 ± 42 |
WAIT 16 | Preclinical | neg. | neg. | − | 3/21, 525 ± 47 | |
ICJ: +s.pl.* | ICJ: − | |||||
4 (n = 6) | WAIT 11 | Preclinical | neg. | pos. | – | 3/20, 567 ± 58 |
WAIT 12 | Preclinical | neg. | pos. | + (+) | 17/20, 396 ± 28 (~) | |
WAIT 13 | Preclinical | neg. | pos. | + | 14/20, 449 ± 19 (~) | |
WAIT 14 | Preclinical | neg. | pos. | ++ | 20/20, 362 ± 12 | |
WAIT 19 | Preclinical | neg. | inconcl. | + | 10/20, 473 ± 17 (~) | |
WAIT 20 | Preclinical | neg. | pos. | ++ (+) | 20/20, 315 ± 11 | |
6 (n = 6) | WAIT 05 | Preclinical | neg. | pos. | ++ | 19/20, 307 ± 15 |
WAIT 06 | Preclinical | neg. | pos. | ++ | 19/20, 368 ± 16 | |
WAIT 07 | Preclinical | neg. | pos. | + (+) | 19/20, 383 ± 15 (~) | |
WAIT 08 | Preclinical | neg. | pos. | ++ (+) | 20/20, 319 ± 8 | |
WAIT 09 | Preclinical | neg. | pos. | ++ | 20/20, 366 ± 14 | |
WAIT 10 | Preclinical | neg. | pos. | + | 19/20, 383 ± 16 | |
8 (n = 2) | WAIT 02 | Preclinical | neg. | neg. | ++ (+) | 18/20, 401 ± 21 |
WAIT 03 | Preclinical | neg. | pos. | +++ | 18/20, 396 ± 12 | |
8 (n = 2) | WAKT 01 | Negative control | neg. | neg. | − | 0/20, > 730 |
WAKT 02 | Negative control | neg. | neg. | − | 0/20, > 730 | |
35 (n = 1) | WAIT 04 | 3 (Positive control) | pos. | pos. | +++ | Not done |
36 (n = 1) | WAIT 01 | 2 (Positive control) | pos. | pos. | ++ (+) | Not done |