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Table 2 Vaccine strains carrying plasmid pS-SaoA confer protection against i.p. challenge with SS2 in BALB/c mice

From: Salmonella enterica serovar Choleraesuis vector delivering SaoA antigen confers protection against Streptococcus suis serotypes 2 and 7 in mice and pigs

Groups Genotypes Percentage of survival (Number of mice Survival/Total)a
rSC0018(pS-SaoA) ΔasdA33 0% (0/10)
rSC0018(pYA3493) ΔasdA33 0% (0/10)
rSC0016(pS-SaoA) ΔPcrp527::TT araC PBAD crp Δpmi-2426 ΔrelA199::araC PBAD lacI TT ΔsopB1686 ΔasdA33 100%** (10/10)
rSC0016(pYA3493) ΔPcrp527::TT araC PBAD crp Δpmi-2426 ΔrelA199::araC PBAD lacI TT ΔsopB1686 ΔasdA33 0% (0/10)
rSC0011(pS-SaoA) ΔPcrp527::TT araC PBAD crp Δpmi-2426 ΔrelA199::araC PBAD lacI TT ΔasdA33 40% (4/10)
rSC0011(pYA3493) ΔPcrp527::TT araC PBAD crp Δpmi-2426 ΔrelA199::araC PBAD lacI TT ΔasdA33 0% (0/10)
BSG NA 0% (0/10)
  1. ** P < 0.01 for the survival of mice immunized with rSC0016(pS-SaoA) compared with survival of mice immunized with rSC0011(pS-SaoA) or BSG.
  2. aMice were challenged by i.p. with 25 × LD50 of SS2 at 7 weeks after immunization; This experiment was performed twice with same results. The data showed the result of the single experiment.