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Figure 2 | Veterinary Research

Figure 2

From: Pigeon paramyxovirus type 1 from a fatal human case induces pneumonia in experimentally infected cynomolgus macaques (Macaca fascicularis)

Figure 2

Pulmonary histopathology and immunohistochemistry of experimental hPPMV-1/Netherlands/579/2003-infection in cynomolgus macaques. A Pulmonary section of macaque #1. Diffuse alveolar damage. There is edema fluid and inflammatory cells in the alveolar lumina (H&E. Original magnification ×2). B Pulmonary section of macaque #1. Diffuse alveolar damage. There are macrophages, lymphocytes, neutrophils, and rare eosinophils, mixed with fibrin strands, in the alveolar lumen (H&E. Original magnification ×40). C Pulmonary section of macaque #1. Diffuse alveolar damage. In addition to inflammatory cells, there is abundant edema fluid in the alveolar lumen (H&E. Original magnification ×40). D Pulmonary section of macaque #1. Diffuse alveolar damage. Hyaline membranes lining the alveolar walls (H&E. Original magnification ×20). E Pulmonary section of macaque #1. Diffuse alveolar damage. There is loss of epithelial cells from the bronchiolar wall (H&E. Original magnification ×40). F Pulmonary section of macaque #2. Diffuse alveolar damage. Hypertrophy of type II pneumocytes lining the alveolar wall (H&E. Original magnification ×40). G Pulmonary section of macaque #2. Diffuse alveolar damage. Expression of PPMV-1 in epithelial cells of the alveoli (immunoperoxidase stain for PPMV-1. Original magnification ×40). H Pulmonary section of macaque #1. Diffuse alveolar damage. Expression of PPMV-1 in type I pneumocytes and type II pneumocytes (immunoperoxidase stain for PPMV-1. Original magnification ×100).

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