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Table 3 Distribution of the mutant viruses in mice organs

From: Glycosylation at 11Asn on hemagglutinin of H5N1 influenza virus contributes to its biological characteristics

Virus Virus replication in experimentally infected mice [number of virus-positive mice/number tested mice (mean titer ± SD)]
Lung Liver Spleen Kidneys Brain Heart
3 dpi 6 dpi 3 dpi 6 dpi 3 dpi 6 dpi 3 dpi 6 dpi 3 dpi 6 dpi 3 dpi 6 dpi
rSY 3/3 (3.3 ± 1) 3/3 (4.0 ± 0.5) 0/3 0/3 0/3 0/3 0/3 0/3 2/3 (0.8 ± 0) 0/3 0/3 0/3
rSY-Δ10 3/3 (2.9 ± 1.3) 3/3 (4.2 ± 0.6) 0/3 0/3 0/3 1/3 (0.5 ± 0) 2/3 (0.5 ± 0.2) 2/3 (0.8 ± 0.3) 0/3 0/3 2/3 (1 ± 0.5) 1/3 (0.3 ± 0)
rSY-Δ11 0/3 0/3 0/3 0/3 0/3 0/3 0/3 0/3 0/3 0/3 0/3 0/3
rSY-Δ10/11 1/3 (1.5 ± 0) 0/3 0/3 0/3 0/3 0/3 0/3 0/3 0/3 0/3 0/3 0/3
  1. 6-week-old BALB/c mice were infected intranasally with 104 EID50 of each virus in a 50 μL volume. Organs were collected on days 3 and 6 post-inoculation, and clarified homogenates were titrated for virus infectivity in eggs at initial dilution of 1:10 (lung), 1:2 (other tissues), or undiluted if negative at the lowest dilution.
  2. dpi: days post-infection.