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Table 2 Determination of intravenous pathogenicity indexes for the mutant viruses

From: Glycosylation at 11Asn on hemagglutinin of H5N1 influenza virus contributes to its biological characteristics

Recombinant virus IVPIs
SY (wild-type) 3
rSY-Δ10 3
rSY-Δ11 2.89
rSY-Δ10/11 2.86
  1. 6-week-old SPF white leghorn chickens (10 chickens per group) were inoculated intravenously with 0.1 mL of 1:10 dilution of allantoic fluid containing each virus. Experimental SPF chickens were monitored daily for clinical signs of disease for 10 days, and the intravenous pathogenicity indexes (IVPI) were calculated according to the recommendation of the OIE.