Table 2 Candidate immunogen list
Protein | Accession Number (NCBI) | Function/putative role in virulence |
|---|---|---|
ApfA | YP_001053581.1 | Fimbrial subunit protein, demonstrated role in A. pleuropneumoniae colonization and virulence [56] |
APP7_2042 | WP_005616333.1 | Putative ligand-gated iron transporter |
HecB | ACE61667.1 | Hemolysin activation protein and putative virulence factor in Arcobacter butzleri [67] |
HgbA | YP_001053746.1 | Hemoglobin binding protein, A. pleuropneumoniae ΔhgbA mutants exhibit an attenuated virulence [54] |
Irp | ABN74015.1 | Iron-regulated OM receptor/transporter possibly involved in hemin transport, upregulated in A. pleuropneumoniae after colonisation [58] |
OstA | YP_001053661.1 | Organic solvent tolerance protein in Helicobacter pilori. OstA inactivation causes altered membrane permeability, sensitivity to organic solvent and susceptibility to antibiotics [68] |
PepN | ABN74424.1 | Multi-subunit transmembrane metalloprotease able to degrade porcine IgA and IgG, expressed during A. pleuropneumoniae infection in vivo [55] |
SlyB | ABN73145.1 | Outer membrane lipoprotein, contributes to cell envelope integrity in Burkholderia multivorans [69] and is linked to the stress response to Mg2Â +Â depletion [70] |
VacJ | YP_001054603.1 | OM lipoprotein, Pasteurella multocida VacJ protein moderately immunogenic and protective when inoculated in vivo [63] |