Experimental design and sample collection. All abbreviations used in Figure 1 are summarized in the black rectangular box. The top line indicates the day post PEDV challenge and the corresponding day post vaccination at which the main events including vaccinations, G2b PEDV challenge, and necropsies occurred. The pigs were housed in groups of 7–8 and were vaccinated with a live G1b PEDV virus (blue boxes), an inactivated G2b PEDV virus (black boxes) or were sham-vaccinated or sham-challenged (green boxes). Red boxes indicate G2b PEDV challenge.