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Table 1 Distribution of CZ and JY viruses and their recombinant viruses in mouse organs at 3 and 5 dpi

From: Synergistic effect of PB2 283M and 526R contributes to enhanced virulence of H5N8 influenza viruses in mice

Virus Virus titer (log10EID50/1 mL ± SD)
Heart Liver Spleen Lung Kidney Brain
3 dpi 5 dpi 3 dpi 5 dpi 3 dpi 5 dpi 3 dpi 5 dpi 3 dpi 5 dpi 3 dpi 5 dpi
wt-CZ 2.13 ± 0.53 3.63 ± 0.18 1.63 ± 0.18 3.25 ± 0.15 4.00 ± 0.00   5.63 ± 0.53 5.75 ± 0.00 2.25 ± 0.00 3.13 ± 0.18 2.25 ± 0.71 5.38 ± 0.18
r-CZ 1.75 ± 0.00 3.25 ± 0.00 3.13 ± 0.53 3.00 ± 0.35 1.50 ± 0.35 5.63 ± 0.18 5.63 ± 0.18 1.38 ± 0.18 3.63 ± 0.18 2.25 ± 0 5.63 ± 0.18
CZ-JYPB2 1.75 ± 0.71 2.00 ± 0.35 1.63 ± 0.18 3.88 ± 0.88 5.25 ± 0.71 1.88 ± 0.88 1.75 ± 0.71
CZ-JYPB1 1.50 ± 0.35 1.88 ± 0.88 2.25 ± 0.71 2.00 ± 0.35 4.00 ± 1.06 5.13 ± 0.53 1.75 ± 0.00 1.25 ± 0.00 1.50 ± 0.35 2.75 ± 0.00
CZ-JYPA 1.25 ± 0.00 2.00 ± 0.35 1.38 ± 0.18 1.50 ± 0.35 5.00 ± 0.35 5.00 ± 0.35 1.38 ± 0.18 1.25 ± 0.00 1.38 ± 0.18
CZ-JYHA 1.38 ± 0.18 2.63 ± 0.18 3.00 ± 0.35 4.88 ± 0.53 5.38 ± 0.53 2.13 ± 0.53 1.50 ± 0.35 1.50 ± 0.35 3.50 ± 0.00
CZ-JYNP 1.25 ± 0.00 3.13 ± 0.53 1.50 ± 0.35 4.63 ± 0.53 5.50 ± 0.35 1.38 ± 0.18 2.38 ± 0.18 1.5 ± 0.35 4.38 ± 0.18
CZ-JYNA 2.63 ± 0.18 3.38 ± 0.18 1.75 ± 0.71 3.25 ± 0.00 2.13 ± 1.24 5.00 ± 0.35 4.75 ± 0.35 3.25 ± 0.00 2.00 ± 0.35 1.88 ± 0.53 3.50 ± 0.00
CZ-JYM 3.50 ± 0.00 3.25 ± 1.41 1.88 ± 0.88 3.50 ± 0.35 2.63 ± 0.18 5.38 ± 0.18 5.75 ± 0.00 1.88 ± 0.53 3.00 ± 0.71 2.63 ± 0.18 4.00 ± 1.06
CZ-JYNS 1.88 ± 0.53 3.00 ± 0.71 2.25 ± 0.71 5.25 ± 0.00 4.13 ± 0.53 2.25 ± 0.00 2.00 ± 0.35 3.00 ± 0.71
wt-JY 2.93 ± 0.50 2.63 ± 0.18 3.63 ± 0.18
r-JY 3.75 ± 0.00 3.13 ± 0.88
JY-CZPB2 3.13 ± 0.53 2.63 ± 0.18 1.50 ± 0.35 5.50 ± 0.00 4.88 ± 0.53 1.63 ± 0.18 2.00 ± 0.35
JY-CZPB1 2.88 ± 0.88 3.63 ± 0.18
JY-CZPA 3.00 ± 0.71 3.63 ± 0.18
JY-CZHA 4.00 ± 0.35 3.00 ± 0.35
JY-CZNP 4.50 ± 0.00 3.75 ± 0.35
JY-CZNA 3.13 ± 0.53 2.63 ± 0.18
JY-CZM 4.38 ± 0.18 3.50 ± 0.00
JY-CZNS 4.25 ± 0.71 3.88 ± 0.53