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Figure 6 | Veterinary Research

Figure 6

From: Synergistic effect of PB2 283M and 526R contributes to enhanced virulence of H5N8 influenza viruses in mice

Figure 6

virulence of HPAI H5N1 S and its mutated viruses in mice. Six-week-old female BALB/c mice were intranasally inoculated with each indicated virus at a different dose (103.0–106.0 EID50) or 50 μL of PBS as controls. Average body weight of surviving mice in each group (n = 5/group) up to 14 dpi are represented as percentages of the original weight on day 0. The error bars represent standard deviations (SD). Weight change is depicted for the mice infected with the A r-S, the B SPB2-K526R and the C SPB2-M283I-K526R. Survival rate of mice infected with indicated viruses, the D r-S, the E SPB2-K526R and the F SPB2-M283I-K526R.

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