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Figure 4 | Veterinary Research

Figure 4

From: Synergistic effect of PB2 283M and 526R contributes to enhanced virulence of H5N8 influenza viruses in mice

Figure 4

Polymerase activities of reconstituted RNP complex and correlation of virulence of recombinant virus with polymerase activity. Comparison of polymerase activities of different ribonucleoprotein complexes with A indicated a single polymerase gene or NP from the CZ or JY virus, and with B indicated two or three polymerase genes from the CZ or JY virus, and with C indicated single or double substitution in the PB2 of the CZ or JY virus. Values represent the mean ± SD of the results of three independent experiments and are standardized to those of the JY (100%). The relative polymerase activity value of each recombinant virus was compared with that of the corresponding parental virus (*P < 0.05; **P < 0.01). D Correlation of virulence of recombinant virus with polymerase activity. The MLD50 of viruses were plotted (inverted axis) against their polymerase activities.

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