Figure 1

Overview of the results of challenge with bovine BSE (1 ^st passage) in goats with five different genotypes. Each symbol represents an individual goat. Symbol colours: empty, yellow, red and black represents TSE negative, preclinical PrP^D (positivity in peripheral sites), late preclinical (PrP^D positivity in CNS, no clear clinical signs) and clinical cases (these are also PrP^D positive in periphery and CNS). Symbol shapes represent location of experiment: circles, lab 1, triangles lab 2 (see also “Materials and methods” section). The two arrows under the X-axis: open and bold indicate respectively the month after inoculation at which respectively the first preclinical and clinical cases were observed.