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Table 5 Proteins of increased or decreased abundance in macrophages in response to S. Enteritidis infection

From: Differential protein expression in chicken macrophages and heterophils in vivo following infection with Salmonella Enteritidis

Acc. no.

Protein name

Gene ID

Fold ratio inf:noninf

Fold ratio vac:noninf

Function

P28318

MRP126, calprotectin

MRP126

15.67*

5.01*

Calcium and zinc binding

Q6QLQ5

Cathelicidin-1

CATHL1

7.32*

2.95*

Antimicrobial peptide

P30374

Ribonuclease homolog

RSFR

5.84*

1.66

Lysosomal cysteine protease

F1NIX4

Trans-2-enoyl-CoA reductase

MECR

5.47*

3.99*

Fatty acid elongation

P46156

Gallinacin 1

GAL1

4.15*

1.12

Antimicrobial protein

F1N8Q1

Superoxide dismutase

SOD1

4.01*

2.58

Oxygen scavenger

P08940

Myeloid protein 1

LECT2

3.87*

1.35

Chemotactic factor for Het

F1P4F3

Lymphocyte antigen 86, MD-1

LY86

3.53*

3.03

Inhibits LPS response of immune cells

F1NS91

60S ribosomal protein L9

RPL9

3.51*

3.82

Structural part of ribosome

E1BTT4

Trifunctional enzyme subunit beta, mitochondrial

HADHB

3.38*

3.54*

β-Oxidation of fatty acids

P43233

Cathepsin B

CTSB

2.88*

2.57*

Lysosomal cysteine protease

B4X9P4

Microsomal glutathione S-transferase 1

MGST1

2.87*

1.46

Membrane protection from oxidative stress

Q5ZMP2

Syntaxin 7

STX7

2.72*

2.94*

Late endosome–lysosome fusion

E1C0F3

Ras-related protein Rab-7a

RAB7A

2.69*

2.38*

Involved in endocytosis, phagosome–lysosome fusion

F1N9J7

Tubulin alpha-3 chain

Tuba3a

2.63*

1.96

Major constituent of microtubules

P08267

Ferritin heavy chain

FTH

2.62*

2.33*

Storage of iron in a soluble, nontoxic state

P02263

Histone H2A-IV

H2A4

2.61*

3.64*

Formation of nucleosome

F1NWG2

Cathepsin C

CTSC

2.48*

2.46*

Activates serine proteases

Q2IAL7

Cathelicidin-2

CATHL2

2.45*

1.01

Antimicrobial peptide

Q6EE32

Calreticulin

CALR

2.33*

2.21*

Molecular chaperon

Q9I9D1

Voltage-dependent anion-selective channel protein 2

VDAC2

2.27*

2.07*

Inhibits mitochondrial way of apoptosis

P02607

Myosin light polypeptide 6

MYL6

2.7*

1.66

Found in phagosome

F1NB92

Endoplasmic reticulum aminopeptidase 1

ERAP1

2.21*

2.04

Antigen processing and presentation of endogenous peptide via MHC class I

E1BTT8

Lactate dehydrogenase A

LDHA

2.07*

1.71

Glycolysis

R4GM10

Fructose-bisphosphate aldolase C

ALDOC

2.07*

2.33

Glycolysis

P24367

Peptidyl-prolyl cis–trans isomerase B

PPIB

2.00*

0.97

Regulation of protein folding and maturation

Q5ZKQ9

RNA binding motif protein, X-linked

RBMX

0.49*

0.59

Regulation of pre- and post-transcriptional processes

R4GGZ2

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4

NDUFA4

0.38*

0.65

Oxidative phosphorylation

E1BYF8

Formin-binding protein 1

FNBP1

0.33*

0.47*

Role in late stage of clathrin-mediated endocytosis

R4GJP1

Family with sequence similarity 107, member B

FAM107

0.32*

0.30*

Candidate tumor suppressor gene

P31395

Stathmin 1

STMN1

0.27*

0.51

Promotes disassembly of microtubules

E1BQI4

Glyoxalase domain-containing protein 4

GLOD4

0.21*

0.18*

Unknown

Q5ZM25

Obg-like ATPase 1

OLA1

0.12*

0.11

Negative role in cell adhesion and spreading

  1. * Significantly different from the expression in macrophages from the non-infected chickens.
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Veterinary Research

ISSN: 1297-9716