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Table 5 Proteins of increased or decreased abundance in macrophages in response to S. Enteritidis infection

From: Differential protein expression in chicken macrophages and heterophils in vivo following infection with Salmonella Enteritidis

Acc. no. Protein name Gene ID Fold ratio inf:noninf Fold ratio vac:noninf Function
P28318 MRP126, calprotectin MRP126 15.67* 5.01* Calcium and zinc binding
Q6QLQ5 Cathelicidin-1 CATHL1 7.32* 2.95* Antimicrobial peptide
P30374 Ribonuclease homolog RSFR 5.84* 1.66 Lysosomal cysteine protease
F1NIX4 Trans-2-enoyl-CoA reductase MECR 5.47* 3.99* Fatty acid elongation
P46156 Gallinacin 1 GAL1 4.15* 1.12 Antimicrobial protein
F1N8Q1 Superoxide dismutase SOD1 4.01* 2.58 Oxygen scavenger
P08940 Myeloid protein 1 LECT2 3.87* 1.35 Chemotactic factor for Het
F1P4F3 Lymphocyte antigen 86, MD-1 LY86 3.53* 3.03 Inhibits LPS response of immune cells
F1NS91 60S ribosomal protein L9 RPL9 3.51* 3.82 Structural part of ribosome
E1BTT4 Trifunctional enzyme subunit beta, mitochondrial HADHB 3.38* 3.54* β-Oxidation of fatty acids
P43233 Cathepsin B CTSB 2.88* 2.57* Lysosomal cysteine protease
B4X9P4 Microsomal glutathione S-transferase 1 MGST1 2.87* 1.46 Membrane protection from oxidative stress
Q5ZMP2 Syntaxin 7 STX7 2.72* 2.94* Late endosome–lysosome fusion
E1C0F3 Ras-related protein Rab-7a RAB7A 2.69* 2.38* Involved in endocytosis, phagosome–lysosome fusion
F1N9J7 Tubulin alpha-3 chain Tuba3a 2.63* 1.96 Major constituent of microtubules
P08267 Ferritin heavy chain FTH 2.62* 2.33* Storage of iron in a soluble, nontoxic state
P02263 Histone H2A-IV H2A4 2.61* 3.64* Formation of nucleosome
F1NWG2 Cathepsin C CTSC 2.48* 2.46* Activates serine proteases
Q2IAL7 Cathelicidin-2 CATHL2 2.45* 1.01 Antimicrobial peptide
Q6EE32 Calreticulin CALR 2.33* 2.21* Molecular chaperon
Q9I9D1 Voltage-dependent anion-selective channel protein 2 VDAC2 2.27* 2.07* Inhibits mitochondrial way of apoptosis
P02607 Myosin light polypeptide 6 MYL6 2.7* 1.66 Found in phagosome
F1NB92 Endoplasmic reticulum aminopeptidase 1 ERAP1 2.21* 2.04 Antigen processing and presentation of endogenous peptide via MHC class I
E1BTT8 Lactate dehydrogenase A LDHA 2.07* 1.71 Glycolysis
R4GM10 Fructose-bisphosphate aldolase C ALDOC 2.07* 2.33 Glycolysis
P24367 Peptidyl-prolyl cis–trans isomerase B PPIB 2.00* 0.97 Regulation of protein folding and maturation
Q5ZKQ9 RNA binding motif protein, X-linked RBMX 0.49* 0.59 Regulation of pre- and post-transcriptional processes
R4GGZ2 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 NDUFA4 0.38* 0.65 Oxidative phosphorylation
E1BYF8 Formin-binding protein 1 FNBP1 0.33* 0.47* Role in late stage of clathrin-mediated endocytosis
R4GJP1 Family with sequence similarity 107, member B FAM107 0.32* 0.30* Candidate tumor suppressor gene
P31395 Stathmin 1 STMN1 0.27* 0.51 Promotes disassembly of microtubules
E1BQI4 Glyoxalase domain-containing protein 4 GLOD4 0.21* 0.18* Unknown
Q5ZM25 Obg-like ATPase 1 OLA1 0.12* 0.11 Negative role in cell adhesion and spreading
  1. * Significantly different from the expression in macrophages from the non-infected chickens.