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Table 3 Proteins which increased in abundance in heterophils in response to S. Enteritidis infection

From: Differential protein expression in chicken macrophages and heterophils in vivo following infection with Salmonella Enteritidis

Acc. no.

Protein name

Gene ID

Fold ratio Inf: noninf

Fold ratio vac: noninf

Function

P02701

Avidin

AVD

55.57*

32.06*

Biotin binding

F1P4F4

Translocon-associated protein

SSR1

9.22*

6.36

Protein translocase

P17785

Annexin A2

ANXA2

6.44*

2.11

Activates macrophages for cytokine production

E1BWG1

Coagulation factor XIIIA

F13A

5.63*

2.60*

Crosslinking of fibrin chains, entrapment of bacteria

R4GJX3

Interferon-induced transmembrane protein

IFITM

4.99*

1.73

Acidification of the endosomal compartments, mediator of the host antiviral response

F1NK96

Protein disulfide-isomerase A6

PDIA6

4.33*

2.66*

Protein foldase

F1NVA4

Nucleophosmin

NPM1

3.68*

1.87

Alarmin, nuclear chaperon

F1NT28

Inorganic pyrophosphatase

PPA1

3.52*

1.67

Hydrolysis of inorganic pyrophosphate (PPi)

Q90593

78 kDa glucose-regulated protein

BiP

3.44*

1.94

Chaperon

F1NWB7

Endoplasmin

HSP90B1

3.33*

1.99

Chaperon

E1C1D1

Annexin 7

ANXA7

3.27*

2.68*

Granular membranes fusion and degranulation

P24367

Peptidyl-prolyl cis–trans isomerase B

PPIB

3.26*

2.23*

Regulation of protein folding and maturation

E1C2S1

Talin-1

TLN1

3.12*

2.56*

Activation of neutrophils

Q49B65

EF hand-containing protein 1

EFHD1

3.12*

1.72

Calcium binding

F1NWG2

Cathepsin C

CTSC

3.10*

1.99

Activates serine proteases (elastase, cathepsin G and granzymes)

F1NDY9

Protein disulfide-isomerase A4

PDIA4

2.93*

1.86

Protein foldase

E1C8M9

Calnexin

CANX

2.88*

1.75

Integral protein of the endoplasmic reticulum

E1BQN9

Calcyclin-binding protein

CACYBP

2.88*

2.38*

Calcium-dependent ubiquitination

H9L340

ATP synthase subunit beta

ATP5B

2.82*

1.56

Energy metabolism

F1NB92

Endoplasmic reticulum aminopeptidase 1

ERAP1

2.78*

0.89

Antigen processing and presentation of endogenous peptide via MHC class I

  1. * Significantly different from the expression in heterophils from the non-infected chickens.
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Veterinary Research

ISSN: 1297-9716