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Table 3 Proteins which increased in abundance in heterophils in response to S. Enteritidis infection

From: Differential protein expression in chicken macrophages and heterophils in vivo following infection with Salmonella Enteritidis

Acc. no. Protein name Gene ID Fold ratio Inf: noninf Fold ratio vac: noninf Function
P02701 Avidin AVD 55.57* 32.06* Biotin binding
F1P4F4 Translocon-associated protein SSR1 9.22* 6.36 Protein translocase
P17785 Annexin A2 ANXA2 6.44* 2.11 Activates macrophages for cytokine production
E1BWG1 Coagulation factor XIIIA F13A 5.63* 2.60* Crosslinking of fibrin chains, entrapment of bacteria
R4GJX3 Interferon-induced transmembrane protein IFITM 4.99* 1.73 Acidification of the endosomal compartments, mediator of the host antiviral response
F1NK96 Protein disulfide-isomerase A6 PDIA6 4.33* 2.66* Protein foldase
F1NVA4 Nucleophosmin NPM1 3.68* 1.87 Alarmin, nuclear chaperon
F1NT28 Inorganic pyrophosphatase PPA1 3.52* 1.67 Hydrolysis of inorganic pyrophosphate (PPi)
Q90593 78 kDa glucose-regulated protein BiP 3.44* 1.94 Chaperon
F1NWB7 Endoplasmin HSP90B1 3.33* 1.99 Chaperon
E1C1D1 Annexin 7 ANXA7 3.27* 2.68* Granular membranes fusion and degranulation
P24367 Peptidyl-prolyl cis–trans isomerase B PPIB 3.26* 2.23* Regulation of protein folding and maturation
E1C2S1 Talin-1 TLN1 3.12* 2.56* Activation of neutrophils
Q49B65 EF hand-containing protein 1 EFHD1 3.12* 1.72 Calcium binding
F1NWG2 Cathepsin C CTSC 3.10* 1.99 Activates serine proteases (elastase, cathepsin G and granzymes)
F1NDY9 Protein disulfide-isomerase A4 PDIA4 2.93* 1.86 Protein foldase
E1C8M9 Calnexin CANX 2.88* 1.75 Integral protein of the endoplasmic reticulum
E1BQN9 Calcyclin-binding protein CACYBP 2.88* 2.38* Calcium-dependent ubiquitination
H9L340 ATP synthase subunit beta ATP5B 2.82* 1.56 Energy metabolism
F1NB92 Endoplasmic reticulum aminopeptidase 1 ERAP1 2.78* 0.89 Antigen processing and presentation of endogenous peptide via MHC class I
  1. * Significantly different from the expression in heterophils from the non-infected chickens.