Table 1 Twenty most characteristic proteins of heterophils (Het) compared to macrophages (Ma)
Acc. no. | Protein name | Gene ID | ∆PSMa | Fold ratio Het:Ma | Response to the infection | Function |
|---|---|---|---|---|---|---|
P28318 | MRP126, calprotectin | MRP126 | 7170 | 9.07 | No | Calcium and zinc binding |
P08940 | Myeloid protein 1 | LECT2 | 5532 | 6.32 | Decrease | Chemotactic factor for Het |
P02789 | Ovotransferrin | OTFB | 2351 | 4.87 | Decrease | Iron binding, immune response |
O73790 | Heterochromatin-associated protein MENT | SERPINB10 | 1760 | 6.00 | No | DNA condensation, cysteine protease inhibitor |
E1C0K1 | Extracellular fatty acid-binding protein | ExFABP | 1742 | 4.94 | No | Fatty acid and bacterial siderophores binding |
F1NG13 | Transglutaminase 3 | TGM3 | 1572 | 19.94 | No | Transglutaminase |
Q2IAL7 | Cathelicidin 2 | CATHL2 | 1402 | 7.49 | Decrease | Antimicrobial peptide |
P27042 | Lysozyme G | LYG2 | 989 | 4.57 | Decrease | Antimicrobial peptide |
Q2IAL6 | Cathelicidin 3 | CATHL3 | 936 | 5.37 | No | Antimicrobial peptide |
P00698 | Lysozyme C | LYZ | 839 | 5.17 | Decrease | Antimicrobial peptide |
Q6QLQ5 | Cathelicidin 1 | CATHL1 | 833 | 4.62 | Decrease | Antimicrobial peptide |
E1BTH1 | Leukocyte elastase inhibitor | SERPINB1 | 627 | Only Het | Decrease | Protection against own proteases |
F1P284 | Leukotriene A(4) hydrolase | LTA4H | 603 | 5.78 | Decrease | Epoxide hydrolase and aminopeptidase |
F1NGT3 | Matrix metallopeptidase 9 | MMP9 | 600 | Only Het | Decrease | Degradation of the extracellular matrix |
F2Z4L6 | Serum albumin | ALB | 557 | 4.79 | Decrease | Plasma carrier |
P30374 | Ribonuclease homolog | RSFR | 548 | 6.89 | Decrease | Lysosomal cysteine protease |
R9PXN7 | Hematopoietic prostaglandin D synthase | HPGDS | 504 | 17.79 | No | Cytosolic glutathione S-transferases |
E1BTV1 | Stomatin | STOM | 502 | 23.82 | No | Integral membrane protein |
D2D3P4 | Rab27a | Rab27a | 435 | 88.08 | No | Small GTPase, exocytosis |
R4GI24 | Integrin alpha-D | ITGAD | 379 | 7.73 | No | Adhesion of leukocytes |