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Table 2 AI virus antigen immunohistochemical staining in tissues from Pekin ducks and Chinese geese inoculated by the intrachoanal route or contact-exposed to H5N8 and H5N2 HPAI viruses

From: Infectivity, transmission and pathogenicity of H5 highly pathogenic avian influenza clade 2.3.4.4 (H5N8 and H5N2) United States index viruses in Pekin ducks and Chinese geese

Species Virus Detection of AI virus antigen in tissues
Nasal ep. Trachea Lung Air sacs Brain Heart Spleen Liver Skeletal muscle Pancreas Cloacal bursa Cecal tonsils Harderian gland Thymus
Pekin ducks 4 dpi H5N8 ++/+ +/++ +/++ +++/+ +/+ +/+ ++/+ −/− +/+ −/− +/− −/− ++/++ −/−
H5N2 +/+ +/+ +/− +/+ −/+ −/− −/− −/− +/− −/− +/− −/− −/− +/−
Chinese geese 4 dpi H5N8 +/++ +/− ++/+ +/− +/+ +/++ ++/+ −/− +/− −/− −/− −/− −/+++ −/+
H5N2 ++/++ +/+ ++/++ +/na ++/++ ++/+++ ++/++ +/+ +/− +/+ +/++ ++/++ −/− ++/+
Chinese geese 8 and 10 dpi H5N2 +/+ +/+ ++/++ na/na +++/+++ ++/++ ++/+ +/+ +/+ +/+ +/++ +/+ na/na +/−
  1. Birds were euthanized at 4, 8 or 10 dpi (bird 1/bird 2).
  2. Kidney, adrenal glands, and intestine were negative for virus antigen staining.
  3. − no positive cells, + single positive cells, ++ scattered groups of positive cells, +++ widespread positivity, na not available.