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Table 1 MDV genes and their respective products involved in immune modulation and pathogenesis

From: Marek’s disease in chickens: a review with focus on immunology

MDV gene (protein) Function Antigenic potential Infection stage Reference
MDV003/078 (vIL-8) Viral chemotactic (CXCL-) protein involved in recruiting immune systems cells to site of viral replication Lytic replication [23, 58]
MDV010 (vLIP) Shares homology to host lipase enzyme and forms covalent bonds with lipids Lytic replication [136]
MDV011/012 Immune evasion protein that down regulates cell surface MHC I expression Lytic replication [52]
MDV012 ORF012 Phosphoprotein required for viral growth both in vivo and in vitro   [137]
MDV040 (gB) Hypothetical function: Virion membrane protein that heterodimerizes with other glycoproteins facilitating viral fusion with host membrane Yes Lytic replication [26, 27]
MDV052/053 UL39/40 (RR) Viral Ribonucleotide Reductase (RR) is essential for replication both in vivo and in vitro Lytic replication [138]
MDV064 (UL49.5) Partially reduces MHC I expression by interacting with TAP protein Lytic replication [53]
MDV073 (pp38) Early protein expressed during cytolytic infection and phosphorylated by Us3p Yes Lytic replication [2629]
MDV092 (Us3p) Serine/threonine protein kinase that phosphorylates pp38 Lytic replication [139]
MDV084/100 (ICP4) Viral gene transactivation function Yes Lytic replication [26, 27]
MDV001a (vTR) Required for integration of viral genome into host DNA for immune evasion, neoplastic transformation and viraemia Latency [140]
MDV006 (pp14) Neurovirulence factor required for PNS neuropathy (acute or transient paralysis) Latency [141]
MDV062 (VP22) Tegument protein essential for viral replication and modulates host cell cycle Latency [142]
MDV057 (gC/UL44) Type 1 transmembrane protein required for horizontal transmission/shedding from feather follicle epithelium Feather follicle shedding [143]
MDV005/076 (MEQ) Viral oncogenic protein involved in T cell neoplastic transformation which forms homodimers and heterodimers with specific intracellular signalling proteins that modulates host cell cycle Yes Neoplastic transformation [26, 27, 35]
MDV029 (pUL17) Co-localizes with VP5 and VP13/14 tegument protein and essential for in vivo viral growth, capsid maturation and DNA packaging Neoplastic transformation [144]