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Figure 3 | Veterinary Research

Figure 3

From: Age is not a determinant factor in susceptibility of broilers to H5N2 clade 2.3.4.4 high pathogenicity avian influenza virus

Figure 3

Histopathological findings in broilers intranasally inoculated with high dose of A/turkey/Minnesota/12582/2015 (H5N2) virus. 5-week old broilers (5w), 8-week old broilers (8w), >30-week-old broiler breeders (>30w); ×40; immunohistochemical detection of viral antigen staining in red. A Cerebellum, 5w. Vacuolation of the molecular and granular layers of the cerebellum with necrosis of the Purkinje neurons. Viral antigen present in the neuropil of both layers (inset). B Heart, 8w. Degeneration and necrosis of myocardiocytes. Extensive intranuclear and intracytoplasmic viral antigen of myocardiocytes (inset). C Lung, 5w. Severe congestion, interstitial edema, and interstitial heterophilic and monocytic infiltration. Viral antigen in epithelium of air capillaries and vascular endothelium (inset). D Spleen, 5w. Multifocal areas of necrosis and depletion of the white pulp. Viral antigen in mononuclear cells (inset). E Pancreas, >30w. Multifocal areas of degeneration of pancreatic acinar cells. Viral antigen in acinar cells (inset). F Kidney, 8w. Focal necrosis of tubular epithelium. Extensive intranuclear and intracytoplasmic viral antigen of tubular epithelial cells (inset). G Adrenal gland, 8w. Diffuse intranuclear and cytoplasmatic viral antigen in corticotropic cells. H Brain, >30w. Viral antigen in ependymal cells of the ventricles. I Skeletal muscle, 8w. Intranuclear and intracytoplasmic viral antigen of myocytes and vascular endothelium.

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