Table 4 Linear mixed regression coefficients and confidence intervals for all statistically significantly different comparisons between time points after inoculation with E. coli and baseline (0 h) for pathogen recognition receptors, chemokines and tissue inhibitor of metallopeptidase 1
From: Oestrous cycle-dependent equine uterine immune response to induced infectious endometritis
Group | Gene | Time (h) | P value | Contrast | (95% CI) |
|---|---|---|---|---|---|
Pathogen recognition receptors | TLR2 | 3 | <0.001 | 4.3 | (2.7, 7) |
12 | 0.005 | 2.0 | (1.2, 3.2) | ||
TLR4 | 3 | <0.001 | 5.5 | (3.4, 9.1) | |
12 | 0.006 | 2.0 | (1.2, 3.3) | ||
48 | 0.007 | 0.5 | (0.3, 0.8) | ||
72 | 0.022 | 0.6 | (0.3, 0.9) | ||
NLRC5 | 3 | 0.018 | 2.3 | (1.2, 4.5) | |
12 | 0.010 | 2.5 | (1.2, 4.9) | ||
Chemokines | CCL2 | 3 | <0.001 | 257.3 | (126.2, 524.3) |
12 | <0.001 | 13.9 | (6.8, 28.3) | ||
24 | <0.001 | 4.4 | (2.2, 9) | ||
48 | 0.001 | 3.3 | (1.6, 6.8) | ||
CXCL9 | 3 | <0.001 | 25.5 | (12.6, 51.5) | |
12 | <0.001 | 126.6 | (62.7, 255.6) | ||
24 | <0.001 | 41.0 | (20.3, 82.8) | ||
48 | <0.001 | 6.6 | (3.3, 13.4) | ||
CXCL10 | 3 | <0.001 | 442.7 | (189.2, 1035.4) | |
12 | <0.001 | 228.1 | (97.5, 533.5) | ||
24 | <0.001 | 17.2 | (7.4, 40.2) | ||
48 | <0.001 | 4.6 | (2, 10.9) | ||
CXCL11 | 3 | <0.001 | 116.4 | (45.1, 301) | |
12 | <0.001 | 388.7 | (150.4, 1004.6) | ||
24 | <0.001 | 23.0 | (8.9, 59.5) | ||
48 | <0.001 | 8.5 | (3.3, 22) | ||
Tissue inhibitor of matrix metallo-peptidases | TIMP1 | 3 | <0.001 | 31.7 | (14.1, 71.5) |
12 | <0.001 | 27.8 | (12.4, 62.7) | ||
24 | <0.001 | 7.4 | (3.3, 16.7) | ||
48 | 0.002 | 3.6 | (1.6, 8.2) | ||
72 | <0.001 | 10.9 | (4.9, 24.6) |