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Table 3 Peripheral tissue immunolabelling following primary passage of sheep with L-BSE

From: L-BSE experimentally transmitted to sheep presents as a unique disease phenotype

Animal ID

Genotype

Clinical status

Survival time (days)

Ganglia

Lymphoid tissues

Muscle

Trige-minal

Nodose

Cranial cervical

Stellate

Coeliaco-mesenteric

ENS

LRLN

MLN

RAMALT

Spleen

PP

Extra-ocular

457/11

AFRQ/AFRQ

+

1236

+

+

–

–

–

–

–

–

–

–

–

+a

112/12

+

1334

+

+

–

–

–

–

–

–

–

–

–

+

26/12

+

1267

+

+

–

–

–

–

–

–

–

–

–

+

98/11

+

1186

+

+

–

nr

–

–

–

–

–

–

–

+a

1606/10

+

867

–

–

–

–

–

–

–

–

–

–

–

–

3/11

ARQ/ARQ

+

959

nr

+

–

–

–

–

–

–

–

–

–

+

182/12

+

1531

+

+

–

–

–

–

–

–

–

–

–

+a

63/11

+

956

nr

+

–

nr

–

–

–

–

–

–

–

+

455/11

+

1186

+

+

–

–

–

–

–

–

–

–

–

+a

3/13

+

1649

+

+

–

–

–

–

–

–

–

–

–

+a

223/13

ARR/ARR

–

1998b

–

–

–

–

–

–

–

–

–

–

–

–

224/13

–

1999b

nr

nr

–

–

–

–

–

–

–

–

–

–

10/14

–

2005b

–

–

–

–

–

–

–

–

–

–

–

–

8/14

–

2000b

–

–

–

–

–

–

–

–

–

–

–

–

9/14

–

2005b

–

–

–

–

–

–

–

–

–

–

–

–

4/12

ARQ/VRQ

+

1389

+

–

–

–

–

–

–

–

–

–

–

+a

140/11

+

957

+

+

+

–

–

–

–

–

–

–

–

+

1591/10

+

803

+

+

–

–

–

–

–

–

nr

–

–

+

267/11

+

1056

nr

+

inc

inc

–

–

–

–

–

–

–

+

58/11

+

864

+

+

–

nr

–

–

–

–

–

–

–

+a

225/13

VRQ/VRQ

–

1964b

–

nr

–

–

–

–

–

–

–

–

–

–

113/12

+

1337

+

+

–

–

–

–

–

–

–

–

–

+a

456/11

+

1183

+

nr

+

–

–

–

–

–

–

–

–

+

48/13

–

1963b

nr

nr

–

inc

+

+

+

+

+

+

+

+

167/12

+

1439

+

+

–

–

–

–

–

–

–

–

–

+

  1. nr: not retrieved; inc: inconclusive, ENS: enteric nervous system, distal ileum, LRLN: lateral retropharyngeal lymph node, MLN: mesenteric lymph node, RAMALT: recto-anal mucosa-associated lymphoid tissue, PP: Peyer’s patches of the distal ileum.
  2. aOccasional positive myocytes in addition to spindle labelling.
  3. bKilled at end of study. No clinical signs.