L-BSE experimentally transmitted to sheep presents as a unique disease phenotype

Simmons, Marion M.; Chaplin, Melanie J.; Konold, Timm; Casalone, Cristina; Beck, Katy E.; Thorne, Leigh; Everitt, Sharon; Floyd, Tobias; Clifford, Derek; Spiropoulos, John

doi:10.1186/s13567-016-0394-1

Veterinary Research

Table 2 Clinical syndromes in sheep challenged with L-type BSE

From: L-BSE experimentally transmitted to sheep presents as a unique disease phenotype

Passage	Animal ID	Genotype	Syndrome	Other neurological and behavioural signs
Primary	456/11	VRQ/VRQ	Cataplectic^a	None
	113/12		Cataplectic	Ataxia
	167/12		Cataplectic	Head tremor, occasionally horizontal nystagmus during collapsing episodes, teeth grinding
	1591/10^b	VRQ/ARQ	Undefined, (possibly pruritic)	Seizure-like episode, positive scratch test
	58/11		Cataplectic	Dullness, ataxia, loss of balance
	4/12		Cataplectic	Head tremor, ataxia
	140/11		Cataplectic	Positive scratch test, head tremor, ataxia
	267/11		Cataplectic	Positive scratch test, ataxia
	63/11	ARQ/ARQ	Pruritic	Dullness, head tremor, ataxia, loss of balance
	3/11		Cataplectic	Positive scratch test, ataxia, loss of balance
	182/12		Pruritic	Positive scratch test, ataxia, loss of balance
	3/13		Cataplectic	Dullness, teeth grinding, absent menace response, ataxia, loss of balance
	455/11		Cataplectic	Positive scratch test, ataxia
	98/11^b	AFRQ/AFRQ	Cataplectic	Ataxia
	457/11		Cataplectic	Head tremor, ataxia
	26/12		Cataplectic	Head tremor, ataxia, loss of balance
	112/12		Cataplectic	Positive scratch test, head tremor, ataxia
Subpassage: donor VRQ/VRQ	112/14	ARQ/ARQ	Cataplectic	Dullness, positive scratch test, absent menace response, head tremor, ataxia, loss of balance, circling
	120/14		Cataplectic	Positive scratch test, absent menace response, head tremor, ataxia, circling, teeth grinding
	119/14		Cataplectic	Positive scratch test, head tremor, ataxia, loss of balance, circling
	107/14		Cataplectic	Absent menace response, head tremor, ataxia, teeth grinding
	108/14		Cataplectic	Head tremor, ataxia, circling
	79/14	ARQ/VRQ	Cataplectic	Positive scratch test, head tremor, loss of balance
	78/14		Cataplectic	Positive scratch test
	76/14		Cataplectic	Head tremor
	6/14		Cataplectic	Ataxia
	73/14		Cataplectic	Absent menace response, head tremor, loss of balance
Subpassage: donor AFRQ/AFRQ	109/14	ARQ/ARQ	Cataplectic	Absent menace response, head tremor
	110/14		Cataplectic	Absent menace response, head tremor, ataxia
	111/14		Cataplectic	Absent menace response, head tremor, ataxia
	118/14		Cataplectic	Absent menace response, head tremor, ataxia
	77/14		Cataplectic	Absent menace response, ataxia
	81/14	ARQ/VRQ	Cataplectic	Head tremor, loss of balance
	80/14		Cataplectic	Head tremor, teeth grinding
	117/14		Cataplectic	Head tremor, ataxia, loss of balance
	82/14		Cataplectic	Head tremor, ataxia, loss of balance, circling

^aCataplexy is spontaneous collapse due to complete atonia of skeletal muscles, often associated with narcolepsy (disorder of normal sleep mechanism, usually excessive sleep). The latter may also be a feature in affected L-type BSE-inoculated sheep but is difficult to diagnose.
^bAnimals selected for subpassage.

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