Distinct functional enrichment of transcriptional signatures in pigs with high and low IFN-gamma responses after vaccination with a porcine reproductive and respiratory syndrome virus (PRRSV)

Table 2 Summary of the number of transcript regulated in PBMCs at 6 weeks post-vaccination

Group	Treatment	Comparator	Up-regulated transcripts (n)	Down-regulated transcripts (n)	Total genes (N)
High responder (HR)	Medium (mock)	Unvaccinated pigs	7	22	29
Low responder (LR) P	Medium (mock)	Unvaccinated pigs	18	109	127
High responder (HR)	PHA	Unvaccinated pigs + PHA	3	11	14
Low responder (LR) P	PHA	Unvaccinated pigs + PHA	4	20	24
High responder (HR)	PRRSV-vaccine	Unvaccinated pigs + vaccine	ns	ns	ns
Low responder (LR)	PRRSV-vaccine	Unvaccinated pigs + vaccine	ns	ns	ns

Non-redundant transcripts with ANOVA P value < 0.001 and a FDR < 0.2 were showed. Details of the genes for which changes in transcript levels were observed are presented in Additional file 1 which shows gene symbols, P values and fold changes.
ns: no statistically significant differences were detected between groups, HR: High responder group, LR: Low responder group.
FDR < 0.2, P < 0.001.

ISSN: 1297-9716