|
Parameter
|
Unit
|
IN high
|
IN low
|
AERO high
|
AERO low
|
Cont.
|
p value for dose groups testing*
|
p value for route groups testing*
|
|---|
|
N = 3
|
N = 2a
|
N = 3
|
N = 4
|
N = 6
|
Cont. vs. high
|
Cont. vs. low
|
Low vs. high
|
Cont. vs. AERO
|
Cont. vs. IN
|
AERO vs. IN
|
|---|
|
V0
|
log10 PFU/mL
|
0.49 [0.48; 0.53]
|
0.41 [0.34; 0.47]
|
0.16 [0.15; 0.22]
|
0.21 [0.07; 0.33]
|
−0.02 [−0.05; 0.01]
|
0.024
|
0.024
|
0.711
|
0.038
|
0.009
|
0.009
|
|
s1
|
log10 PFU/d
|
3.34 [2.52; 3.52]
|
0.45 [0.34; 0.56]
|
1.05 [0.89; 1.18]
|
0.63 [0.50; 0.77]
|
0.63 [0.51; 0.69]
|
0.012
|
0.755
|
0.012
|
0.22
|
0.22
|
0.22
|
|
Tmax
|
d
|
1.42 [1.28; 2.00]
|
5.62 [5.31; 5.93]
|
3.16 [3.01; 3.25]
|
5.12 [4.62; 5.52]
|
5.60 [4.70; 5.72]
|
0.006
|
0.589
|
0.012
|
0.13
|
0.13
|
0.43
|
|
s2
|
log10 PFU/mL/d
|
−0.81 [−0.99; −0.73]
|
−1.41 [−1.92; −0.90]
|
−0.96 [−1.07; −0.83]
|
−1.21 [-1.41; −0.92]
|
−0.68 [−0.73; −0.63]
|
0.11
|
0.15
|
0.33
|
0.048
|
0.261
|
0.837
|
|
Predicted peak
|
log10 PFU/mL
|
4.97 [4.84; 5.09]
|
3.09 [2.25; 3.93]
|
3.18 [2.95; 3.72]
|
3.48 [2.49; 4.40]
|
3.45 [2.43; 3.96]
|
0.34
|
0.98
|
0.34
|
0.82
|
0.47
|
0.47
|
|
Tstart
|
dpi
|
0.16 [0.15; 0.21]
|
1.95 [1.31;2.58]
|
0.80 [0.73; 0.89]
|
1.33 [0.88; 1.87]
|
1.69 [1.42; 1.96]
|
0.018
|
0.579
|
0.054
|
0.32
|
0.32
|
0.66
|
|
Tend
|
dpi
|
6.56 [6.27; 6.65]
|
6.92 [6.48; 7.36]
|
5.96 [5.56; 5.99]
|
7.24 [7.00; 7.39]
|
9.30 [9.11; 9.51]
|
0.012
|
0.012
|
0.024
|
0.012
|
0.012
|
0.831
|
|
Predicted dura tion of shedding period
|
d
|
6.40 [6.06; 6.50]
|
4.97 [3.90; 6.04]
|
5.17 [4.67; 5.26]
|
5.74 [4.86; 6.60]
|
7.52 [6.57; 8.10]
|
0.072
|
0.096
|
0.839
|
0.03
|
0.16
|
0.70
|
- [Q1–Q3]: represents the interval between the first and third quartile; N: number of pigs; Median computed from the individual parameters.
-
a2 pigs do not have a virus-positive sample on any occasion after the challenge.
-
* p value computed from pairwise permtuational t test using 1000 permutation and with p value adjusted for multiple testing using Benjamini & Hochberg method. Cont. is for contact.
