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Table 1 Description of natural atypical scrapie isolates

From: Goat K222-PrPC polymorphic variant does not provide resistance to atypical scrapie in transgenic mice

Isolate PrP genotype Description and references Supplier
Sheep-Sc M45 wta Cerebellum from a natural atypical scrapie case in sheep NEIKERc
Goat-Sc I15 wtb Brain from a natural atypical scrapie case in goat IZSTOd
Goat-Sc 12-09106 wt; H/H154 Cerebellum from a natural atypical scrapie case in goat INIAVe
  1. aWild type (wt) sheep prion protein genotype: A136R154Q171/A136R154Q171.
  2. bWild type (wt) goat prion protein genotype: I142R154R211Q222S240/I142R154R211Q222S240.
  3. cInstituto Vasco de Investigación y Desarrollo Agrario (NEIKER), Vizcaya, Spain.
  4. dIstituto Zooprofilattico Sperimentale de Piemont, Torino (IZSTO) Italy (We than Dr. Pier Luigi Acutis for providing the Goat-Sc I15 isolate).
  5. eLaboratório de Patologia; Instituto Nacional de Investigação Agrária e Veterinária (INIAV); Lisboa, Portugal.