Goat K222-PrPC polymorphic variant does not provide resistance to atypical scrapie in transgenic mice

Table 1 Description of natural atypical scrapie isolates

Isolate	PrP genotype	Description and references	Supplier
Sheep-Sc M45	wt^a	Cerebellum from a natural atypical scrapie case in sheep	NEIKER^c
Goat-Sc I15	wt^b	Brain from a natural atypical scrapie case in goat	IZSTO^d
Goat-Sc 12-09106	wt; H/H₁₅₄	Cerebellum from a natural atypical scrapie case in goat	INIAV^e

^aWild type (wt) sheep prion protein genotype: A₁₃₆R₁₅₄Q₁₇₁/A₁₃₆R₁₅₄Q_171.
^bWild type (wt) goat prion protein genotype: I₁₄₂R₁₅₄R₂₁₁Q₂₂₂S₂₄₀/I₁₄₂R₁₅₄R₂₁₁Q₂₂₂S_240.
^cInstituto Vasco de Investigación y Desarrollo Agrario (NEIKER), Vizcaya, Spain.
^dIstituto Zooprofilattico Sperimentale de Piemont, Torino (IZSTO) Italy (We than Dr. Pier Luigi Acutis for providing the Goat-Sc I15 isolate).
^eLaboratório de Patologia; Instituto Nacional de Investigação Agrária e Veterinária (INIAV); Lisboa, Portugal.

ISSN: 1297-9716