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Table 2 Data and results of all scrapie negative Damascus goats from Cyprus

From: Genetic, histochemical and biochemical studies on goat TSE cases from Cyprus

Goat ZYP Flock (age) Brain stem CM GC Ln. retroph. Tonsil 3rd eye lid Spleen Rectum Placenta
IHC (rapid test) Follicles ENS
I142N146R151R154R211Q222
6 A (7) neg. (0.014) neg. neg. 0/120 neg. 0/45 neg. 0/13 neg. 0/231 NA NA NA
18 H (4) neg. (0.016) neg. neg. 0/97 neg. 0/111 neg. 0/21 neg. 0/3741 neg. 0/9 neg. NA
23 K (6) neg. (0.011) neg. neg. 0/110 neg. 0/64 neg. 0/3 neg. 0/201 neg. 0/116 neg. NA
32 O (4) neg. (0.018) neg. neg. 0/401 0 neg. 0/9 neg. 0/173 neg. 0/47 neg. NA
38 Q (3) neg. (0.010) neg. neg. 0/217 neg. 0/186 0 neg. 0/276 neg. 0/49 neg. NA
42 S (2) neg. (0.007) neg. neg. 0/388 neg. 0/149 neg. 0/1 neg. 0/345 neg. 0/5 neg. neg.
43 S (3) neg. (0.008) neg. neg. 0/98 neg. 0/2 neg. 0/39 neg. 0/313 neg. 0/35 neg. neg.
44 S (4) neg. (0.008) neg. neg. 0/329 neg. 0/73 neg. 0/26 neg. 0/306 neg. 0/46 neg. NA
45 T (5) neg. (0.010) neg. neg. 0/359 neg. 0/132 neg. 0/4 neg. 0/223 neg. 0/16 neg. NA
46 T (4) neg. (0.010) neg. neg. 0/548 neg. 0/195 neg. 0/51 neg. 0/294 neg. 0/14 neg. NA
N/S146
2 A (7) neg. (0.017) neg. neg. 0/219 neg. 0/86 neg. 0/1 neg. 0/267 neg. 0/1 neg. NA
S146
4 A (7) neg. (0.049) neg. neg. 0/230 neg. 0/158 0 neg. 0/106 neg. 0/2 neg. NA
N/D146
28 M (2) neg. (0.010) neg. neg. 0/223 neg. 0/204 neg. 0/18 neg. 0/207 neg. 0/31 neg. NA
M142
36 Q (3) neg. (0.010) neg. neg. 0/131 neg. 0/49 neg. 0/3 neg. 0/270 neg. 0/2 neg. NA
N/D146R/H151
39 Q (4) neg. (0.007) neg. neg. 0/899 neg. 0/2 neg. 0/21 neg. 0/168 neg. 0/3 neg. neg.
  1. D: aspartic acid; I: isoleucine; H: histidine; M: methionine; N: asparagine; Q: glutamine; R: arginine; S: serine; A–T: goat herds; age is given in years; Cut-off BioRad rapid test: 0.213; IHC: immunohistochemistry; +, ++, +++: mild, moderate, severe PrPSc accumulation (the first number indicates the number of positive follicles, the second number the total number of follicles examined); CMGC: celiac and mesenteric ganglion complex; Ln. retroph.: retropharyngeal lymph node; 0: no lymphatic follicles; ENS: enteric nervous system; neg.: PrPSc negative; NA tissue sample not available.