Figure 3

Relationship between PRRSV RNA concentration in fetal thymus and the ratio of \({\mathbf{CD163}}_{{{\mathbf{endo}}}}^{{\mathbf{ + }}}\) : \({\mathbf{CD163}}_{{{\mathbf{plc}}}}^{{\mathbf{ + }}}\) and \({\mathbf{CD169}}_{{{\mathbf{endo}}}}^{{\mathbf{ + }}}\) : \({\mathbf{CD169}}_{{{\mathbf{plc}}}}^{{\mathbf{ + }}}\) . Results of single level proportional odds models. The probability of a fetus being in each of three PRRSV RNA concentration categories is shown: negative (green), low (blue; 0 < log₁₀ copies per mg <5) and high (red; >5 log₁₀ copies per mg). A Based on ratio of \({\text{CD163}}_{{{\text{endo}}}}^{{{ + }}}\):\({\text{CD163}}_{{{\text{plc}}}}^{{{ + }}}\) cells (P = 0.001), the probability of a fetuses being in the high viral load category (red line) increases dramatically as \({\text{CD163}}_{{{\text{endo}}}}^{{{ + }}}\):\({\text{CD163}}_{{{\text{plc}}}}^{{{ + }}}\) ratio increases (opposite true for negative and low viral load categories). B Based on ratio of \({\text{CD169}}_{{{\text{endo}}}}^{{{ + }}}\):\({\text{CD169}}_{{{\text{plc}}}}^{{{ + }}}\) cells (P = 0.07) a similar trend is noted but the strength of association is weak and may not be biologically relevant.