Figure 6
IPS-1 plays an essential role in ATMUV-induced up-regulation of IFN. 293T cells stably expressing specific shRNA targeting IPS-1 or luciferase control were infected with or without ATMUV for 36 h. Quantitative real-time PCR were performed to measure the interference efficiency of IPS-1 (A) and the production of IFN-β, IL-28A/B and IL-29 (B). The mRNA level in the luc-shRNA control cells infected with ATMUV was set to 100. The average results from three independent experiments are plotted. The error bars represent the S.E. *P < 0.05.