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Table 1 Distribution of minimal inhibitory concentrations of porcine CS resistant E. coli isolates in trial 2

From: In vivo therapeutic efficacy and pharmacokinetics of colistin sulfate in an experimental model of enterotoxigenic Escherichia coli infection in weaned pigs

 

Colistin sulfate MIC values (μg/mL)

Isolates

Time

Groups

0.06

0.12

0.25

0.5

1

2

4

8

16

32

M4A3

D3

CT

       

+

  

M4B3

D3

CT

       

+

  

M4C3

D3

CT

       

+

  

M4D3

D3

CT

       

+

  

M6A11

D11

CT

        

+

 

M6C11

D11

CT

       

+

  

M6B11

D11

CT

       

+

  

L10A4a

D4

CU

       

+

  

L1B1

D1

CT

      

+

   
  1. D3 = 3 days post CS treatment; D11 = 11 days post CS treatment; D4 = 4 days post challenge; D1 = 1 day post CS treatment.
  2. The isolates with MIC values higher than resistance breakpoint (MIC > 2 μg/mL) as described by Li et al. [45] were considered resistant.
  3. MIC of ECL8559A <0.06 μg/mL.
  4. CU: challenged untreated; CT: challenged treated.
  5. aIsolate confirmed ETEC: F4 by multiplex PCR.