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Table 1 Distribution of minimal inhibitory concentrations of porcine CS resistant E. coli isolates in trial 2

From: In vivo therapeutic efficacy and pharmacokinetics of colistin sulfate in an experimental model of enterotoxigenic Escherichia coli infection in weaned pigs

  Colistin sulfate MIC values (μg/mL)
Isolates Time Groups 0.06 0.12 0.25 0.5 1 2 4 8 16 32
M4A3 D3 CT         +   
M4B3 D3 CT         +   
M4C3 D3 CT         +   
M4D3 D3 CT         +   
M6A11 D11 CT          +  
M6C11 D11 CT         +   
M6B11 D11 CT         +   
L10A4a D4 CU         +   
L1B1 D1 CT        +    
  1. D3 = 3 days post CS treatment; D11 = 11 days post CS treatment; D4 = 4 days post challenge; D1 = 1 day post CS treatment.
  2. The isolates with MIC values higher than resistance breakpoint (MIC > 2 μg/mL) as described by Li et al. [45] were considered resistant.
  3. MIC of ECL8559A <0.06 μg/mL.
  4. CU: challenged untreated; CT: challenged treated.
  5. aIsolate confirmed ETEC: F4 by multiplex PCR.