Figure 1

Evolution of fecal ETEC: F4 bacterial counts (mean ± standard deviation [SD]). Challenge was performed at d-2 and treatment with colistin sulfate (CS) at a dose of 100 000 IU/kg (trial 1) or 50 000 IU/kg (trial 2) was started at d0 (36 h post challenge) and administered twice daily for a period of 5 days. In the two trials, CS treatment resulted in a significant reduction in fecal ETEC: F4 shedding between d2 and d6 (p < 0.0001). A significantly lower fecal excretion of ETEC: F4 was observed in trial 2 compared to trial 1 between d1 and d3 inclusive (p < 0.0001).