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Table 3 Summary of genes annotated with the three major GO terms identified from functional analysis of the differentially expressed gene lists

From: Live and inactivated Salmonella enterica serovar Typhimurium stimulate similar but distinct transcriptome profiles in bovine macrophages and dendritic cells

  DC_L DC_D Mø_L Mø_D
Inflammatory response CCL20, CCL5, CXCL2, F3, IL1A, IL1B, IL6, KDM6B, MEFV, NFKDID, NFKBIZ, PTX3, TNF, TNFAIP3 CCL20, CCL5, CCR7, CXCL2, F3, IL6, KDM6B, MEFV, NFKB1, OLR1, TNF, TNFAIP3 CD40LG, CCL20, CCL5, CCL8, CCR7, CXCL2, CFB, F3, IL1RN, IL1A, IL1B, IL10, IL6, KDM6B, MEFV, NFDBID, NFKBIZ, OLR1, PTX3, SELP, SAA2, TNF, TNFAIP3, TNFAIP6 CCL20, CCL5, CCL8, CCR4, CCR7, CXCL2, CFB, F3, FOS, IL1A, IL1B, IL10, IL6, KDM6B, MEFV, NFKBID, NFKBIZ, OLR1, PTX3, SELP, SAA2, TNF, TNFAIP3, TNFAIP6
Regulation of programmed cell death BCL2A1, BIRC3, BTG2, CFLAR, CLCF1, CSF2, DUSP1, F3, GCLC, IER3, INHBA, IFIH1, IL1A, IL1B, IL6, NFKBIA, NR4A1, NR4A2, PMAIP1, PIM1, PTGS2, SOCS3, TNF, TNFAIP3, TRAF1, TXNIP, VEGFA BCL2A1, BIRC3, BTG2, CFLAR, CSF2, F3, GCH1, GCLC, IER3, IL6, NFKB1, NFKBIA, NR4A1, NR4A2, PPIF, PMAIP1, PIM3, PLEKHF1, PTGS2, TNF, TNFAIP3, TRAF1, VEGFA BCL2A1, BTG2, CD40LG, CFLAR, CLCF1, CD40LG, CSF2, DUSP1, F3, GDNF, IER3, INHBA, ID3, IFNG, IL1A, IL1B, IL10, IL6, LIG4, LTA, NR4A1, PPIF, PMAIP1, PIM1, PHLDA1, PTGS2, SOCS3, TNF, TNFAIP3, TRAF1, TXNIP, VEGFA BCL2A1, BIRC3, BTG2, CFLAR, CLCF1, CSF2, DLC1, DUSP1, F3, GCLC, GDNF, IER3, INHBA, ID3, IFIH1, IL1A, IL1B, IL10, IL6, LIG4, MX1, NR4A1, PPIF, PMAIP1, PIM1, PLEKHF1, PHLDA1, PTGS2, SERPINB2, SOCS3, TNF, TNFAIP3, TRAF1, VEGFA
Regulation of transcription BAZ1A, BHLHE41, BTG2, CD80, ETS2, GCLC, GZF1, ID2, INHBA, IL1B, IL6, IRF1, KDM6B, KLF5, NFIL3, NFKBIA, NFKBIZ, NR4A1, NR4A2, NR4A3, PIM1, PNRC1, PRDM1, RYBP, SKIL, TNF, TXNIP, VEGFA BAZ1A, BTG2, CARHSP1, CD80, ETS2, ETV3, FOSB, FOXF1, GCLC, GZF1, ICAM1, IL6, IRF1, IRF8, KDM6B, KLF5, MAFF, NFATC1, NFIL3, NFKB1, NFKB2, NFKBIA, NR4A1, NR4A2, NR4A3, PRDM1, RYBP, SAFB2, SFRQ, SKIL, TLE1, TNF, VEGFA, ZBTB10 ATF3, BHLHE40, BHLHE41, BTG2, CD80, CEBPA, CEBPD, CSRNP1, EGR1, EHF, ETS2, GDNF, GZF1, HHEX, ICAM1, ID2, ID3, IFNG, IL1B, IL10, IL6, INHBA, IRF1, KDM6B, KLF13, MAFF, MED4, MTERF, NFATC1, NFIL3, NFKB2, NFKBIZ, NR4A1, PHF10, PPARGC1B, PIM1, PRDM1, RYBP, TNF, TXNIP, VEGFA, ZNF175, ZNF181, ZNF200, ZNF235, ZNF565, ZNF567, ZNF582, ZNF677, ZNF814 ATF3, BAZ1A, BHLHE41, BTG2, CCNL1, CD80, CEBPD, CSRNP1, EHF, ETS2, ETV3, FOS, FOSB, GCLC, GDNF, GTF2B, GZF1, ICAM1, ID1, ID2, ID3, IL1B, IL10, IL6, INHBA, IRF1, IRF4, KDM6B, KLF5, MAFF, NFATC1, NFKB2, NFKBIZ, NR4A1, PIM1, PRDM1, RYBP, SFPQ, SIK1, SKIL, TNF, VEGFA, ZNF132, ZNF582
  1. Differentially expressed genes (FDR < 0.05, fold change >1.8) identified for DC treated with live (DC_L) and inactivated (DC_D) S. Typhimurium and Mø treated with live (Mø _L) and inactivated (Mø _D). Genes are listed by HUGO gene symbol and were identified from functional analysis using human gene annotation data. Those indicated in italics were also identified from analysis using bovine gene annotation data.