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Table 1 Overview of animal experiments presented in this study

From: Repurposing of antiparasitic drugs: the hydroxy-naphthoquinone buparvaquone inhibits vertical transmission in the pregnant neosporosis mouse model

 

Exp I

Exp II

Gender

Males

Females

Groups

4, 6 mice per group

3, 16 mice per group

Mating

No

Yes

Challenge

Nc-Spain 7 (105)

Nc-Spain 7 (105), 7 days post mating

Treatment

ARI, ARO, MEF, placebo; days 2–7 pi

BPQ, placebo; days 2–7 pi

Euthanasia

21 days pi

non-pregnant: 21 days pi dams: 30 days after birth, i.e., 44 days pi

Parameters

N. caninum load in brains and lungs, serum titer

Number of pups, N. caninum brain load, serum titer

  1. Balb/c mice were used throughout the experiment, either males for an in vivo pre-test of artemiside, artemisone or mefloquine (ARI, ARO, MEF; Exp I), or females for assessing the effectiveness of buparvaquone (BPQ) in a pregnant mouse model (Exp. II). pi, post infection with 105 NcSpain7 tachyzoites.
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Veterinary Research

ISSN: 1297-9716