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Table 1 Breed, age, histopathology and disease diagnosis of sheep

From: Variations in IL-23 and IL-25 receptor gene structure, sequence and expression associated with the two disease forms of sheep paratuberculosis

Sheep ID Breed Origina Age (years) SGIb AFBc Tissue specific lesion graded IS900 e Diagnosisf
SH.139 Blackface A 3 5 4 Severe +, + Multibacillary
SH.140 Blackface A 3 7 4 Severe +, + Multibacillary
SH.146 Blackface x B 2.5 5 4 Severe +, + Multibacillary
SH.190 Blackface C 3 5 4 Severe +, + Multibacillary
SH.199 Blackface C 2 6 4 Severe +, + Multibacillary
SH.204 Blackface D 1.5 6 4 Severe +, + Multibacillary
SH.107 Blackface x E 2.5 2.5 0 Mild +, + Paucibacillary
SH.147 Blackface x B 2 3 0 Mild +, + Paucibacillary
SH.155 Blackface F 3 2 0 Mild +, + Paucibacillary
SH.160 Blackface x B 3 2.5 0 Mild +, + Paucibacillary
SH.188 Blackface x B 4 4 1 Moderate +, + Paucibacillary
SH.205 Blackface D 4 2 0 Mild +, + Paucibacillary
K207 Blackface G 2.5 0 0 ND −, − Control
K208 Blackface G 2.5 0 0 ND −, − Control
K213 Blackface G 2.5 0 0 ND −, − Control
K224 Blackface G 2.5 0 0 ND −, − Control
K227 Blackface G 2.5 0 0 ND −, − Control
K229 Blackface G 2.5 0 0 ND −, − Control
  1. aSource farms.
  2. bSeverity of granulomatous inflammation (SGI) grading: based on total number of epithelioid macrophages and leukocyte distribution patterns of the terminal ileum [5].
  3. cAcid fast bacteria (AFB) -; grading: grades 0–2 were defined as paucibacillary; grades 3–4 were defined as multibacillary observed in terminal ileum tissue [5].
  4. dTissue specific lesion grading: for each terminal ileum histological section, the sum of the points (SGI + AFB) was used to determine tissue-specific lesion grades. A severity of “none” was assigned to those with a lesion grade of 0, “mild” was assigned to a lesion grade of ≥2 and ≤3, “moderate” was assigned to those with a lesion grade of >3 and ≤5 and “severe” was assigned to a lesion grade of 6–11.
  5. e IS900 PCR result using each of the two primer sets.
  6. fDiagnosis: based on histopathological observations.