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Table 1 Breed, age, histopathology and disease diagnosis of sheep

From: Variations in IL-23 and IL-25 receptor gene structure, sequence and expression associated with the two disease forms of sheep paratuberculosis

Sheep ID

Breed

Origina

Age (years)

SGIb

AFBc

Tissue specific lesion graded

IS900 e

Diagnosisf

SH.139

Blackface

A

3

5

4

Severe

+, +

Multibacillary

SH.140

Blackface

A

3

7

4

Severe

+, +

Multibacillary

SH.146

Blackface x

B

2.5

5

4

Severe

+, +

Multibacillary

SH.190

Blackface

C

3

5

4

Severe

+, +

Multibacillary

SH.199

Blackface

C

2

6

4

Severe

+, +

Multibacillary

SH.204

Blackface

D

1.5

6

4

Severe

+, +

Multibacillary

SH.107

Blackface x

E

2.5

2.5

0

Mild

+, +

Paucibacillary

SH.147

Blackface x

B

2

3

0

Mild

+, +

Paucibacillary

SH.155

Blackface

F

3

2

0

Mild

+, +

Paucibacillary

SH.160

Blackface x

B

3

2.5

0

Mild

+, +

Paucibacillary

SH.188

Blackface x

B

4

4

1

Moderate

+, +

Paucibacillary

SH.205

Blackface

D

4

2

0

Mild

+, +

Paucibacillary

K207

Blackface

G

2.5

0

0

ND

−, −

Control

K208

Blackface

G

2.5

0

0

ND

−, −

Control

K213

Blackface

G

2.5

0

0

ND

−, −

Control

K224

Blackface

G

2.5

0

0

ND

−, −

Control

K227

Blackface

G

2.5

0

0

ND

−, −

Control

K229

Blackface

G

2.5

0

0

ND

−, −

Control

  1. aSource farms.
  2. bSeverity of granulomatous inflammation (SGI) grading: based on total number of epithelioid macrophages and leukocyte distribution patterns of the terminal ileum [5].
  3. cAcid fast bacteria (AFB) -; grading: grades 0–2 were defined as paucibacillary; grades 3–4 were defined as multibacillary observed in terminal ileum tissue [5].
  4. dTissue specific lesion grading: for each terminal ileum histological section, the sum of the points (SGI + AFB) was used to determine tissue-specific lesion grades. A severity of “none” was assigned to those with a lesion grade of 0, “mild” was assigned to a lesion grade of ≥2 and ≤3, “moderate” was assigned to those with a lesion grade of >3 and ≤5 and “severe” was assigned to a lesion grade of 6–11.
  5. e IS900 PCR result using each of the two primer sets.
  6. fDiagnosis: based on histopathological observations.