Figure 5

Transmission electron micrograph of SAV infected Atlantic salmon myocardium 11 days post-infection. A severely damaged cardiomyocyte (dashed arrows) with still-intact nucleus surrounded by markedly widened interstitial space (asterisk) and presence of leukocytes (arrow); B higher magnification of dashed square of (A) showing multiple membrane bound vesicles, possibly representing autophagy; C end stage cardiomyocyte with very scanty cytoplasm (double dashed arrows) and relatively intact cardiomyocyte (dashed arrow) with abundant interstitial space with cell debris (astrics); D higher magnification of dashed square of (C) showing markedly condensed chromatin in the cell nucleus that still has intact membrane. Note multiple cytoplasmic vesicles (autophagy vacuoles).