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Table 4 Histopathology of several POL2FL6 infected hamsters.

From: Natural transmission of Leishmania infantum through experimentally infected Phlebotomus perniciosus highlights the virulence of Leishmania parasites circulating in the human visceral leishmaniasis outbreak in Madrid, Spain

Tissue Negative control H5.3 H5.4 H6.1 H6.2 H6.3 H7.1 H7.2 H7.3
Salivary glands 0 ND 1 0 ND 0 1 1 0
Stomach 0 ND 2 0 ND 0 2 2 1
Small intestine 0 ND 2 0 0 0 2 2 2
Large intestine 0 ND 1 0 0 0 1 1 1
Mesenteric ganglion 0 ND 3 0 0 0 3 3 3
Heart 0 ND 0 0 0 0 0 0 0
Lung 0 ND 1 0 0 0 1 1 1
Kidney 0 ND 0 1 0 0 1 1 1
Adrenal gland (cortex) 0 ND 2 0 0 0 1 1 1
Liver 0 0 3 0 0 0 3 3 3
Spleen 0 0 3 0 0 0 3 3 3
Pancreas 0 ND 0 0 0 0 0 0 0
Brain 0 ND 0 0 0 0 1 1 0
Bone marrow 0 ND 3 0 0 ND ND ND ND
Skin 0 ND 1 0 0 0 ND 0 ND
Reproductive organs 0 ND 3 0 0 0 2 1 1
  1. Negative control corresponds to a non infected hamster. H5.3, H5.4: Group 5, hamsters 3 and 4 (Leishmania vector-initiated infection). H6.1, H6.2, H6.3: Group 6, hamsters 1, 2 and 3 (Leishmania vector-initiated infection). H7.1, H7.2, H7.3: Group 7, hamsters 1, 2 and 3 (Leishmania intraperitoneal inoculation)
  2. ND, not determined; 0, no amastigote detection; 1, amastigotes hardly seen in localized areas; 2, more abundant presence of amastigotes, generally associated with other lessions such as granulomes or calcium agglomerates and 3, severe Leishmania parasitation