Skip to main content

Table 2 Comparison between S-INDEL PEDV Iowa106- and the original US PEDV PC21A-infection in conventional suckling piglets

From: Experimental infection of a US spike-insertion deletion porcine epidemic diarrhea virus in conventional nursing piglets and cross-protection to the original US PEDV infection

 

PEDV strain

S-INDEL Iowa106 (4 litters; n = 36)

Original US PC21A (l litter; n = 11)

Piglet morbidity

100%

100%

Piglet mortality

18% (0–75%)

55% (NA)

Onset of diarrhea (dpi)

2.06 Â± 0.63 (1–3)*

1.00 Â± 0.00 (1–1)

Duration of diarrhea (RS ≧ 2; days)

4.75 Â± 1.52 (2–7)*

7.20 Â± 0.45 (7–8)

Highest fecal PEDV RNA shedding titer (log10 GE/mL)a

11.67 Â± 1.07 (9.46–13.40)

11.76 Â± 0.91 (10.03–13.13)

VH:CD ratio in jejunumb

2.90 Â± 1.24* (1.36–5.40)

1.40 Â± 0.47 (0.85–1.98)

PEDV antigen score in jejunumb

1.40 Â± 0.70* (1–3)

2.50 Â± 1.00 (1–3)

  1. Data are showed as mean Â± standard deviation (full range).
  2. dpi, days post-inoculation; GE, genomic equivalent; VH:CD, the ratio of villous height:crypt depth; NA, not available.
  3. aIt was detected on the same day of onset of diarrhea.
  4. bPiglets died or euthanized between 2 and 6 dpi.
  5. * Significant difference between Iowa106 and PC21A by student t test (P < 0.05).