Figure 1

Overall layout of the study and its main results. The study comprised four groups (G1-G4) of sheep orally challenged with BSE and their progeny and one group (G5) of sentinel controls and their offspring. AR, attack rate, as percentage. Combined attack rates are: A) for orally dosed susceptible sheep (M₁₁₂T Suffolk sheep excluded) including clinically affected animals and preclinical culls, 104/113 = 92.0%; B) for the susceptible F1 and F2 progeny of infected dams, 14/79 (17.7%); 5) for susceptible sheep exposed only to lateral transmission, 1/205 = 0.5%. For other details see Table 1.